Chapter 1.4. Homolytic Aromatic Substitutions

  1. Prof. Philippe Renaud1 and
  2. Prof. Mukund P. Sibi2
  1. Armido Studer and
  2. Martin Bossart

Published Online: 26 MAR 2008

DOI: 10.1002/9783527618293.ch29

Radicals in Organic Synthesis

Radicals in Organic Synthesis

How to Cite

Studer, A. and Bossart, M. (2001) Homolytic Aromatic Substitutions, in Radicals in Organic Synthesis (eds P. Renaud and M. P. Sibi), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527618293.ch29

Editor Information

  1. 1

    Universite de Fribourg, Institut de Chimie Organique, Pérolles, CH-1700 Fribourg, Switzerland

  2. 2

    Department of Chemistry, North Dakota State University, Fargo, ND 58105, USA

Publication History

  1. Published Online: 26 MAR 2008
  2. Published Print: 29 MAR 2001

ISBN Information

Print ISBN: 9783527301607

Online ISBN: 9783527618293



  • radical arylations;
  • nucleophilic alkyl;
  • hydrogen abstraction;
  • benzene derivatives;
  • frontier molecular orbital theory


Radical arylations can either be performed by SRN1 reactions or by homolytic aromatic substitutions. The SRN1 type reactions have recently been reviewed [1] and will not be included in the present article. Because of space limitations this review will focus on examples mostly from the recent literature. Especially for the older literature, we refer to several good review articles on homolytic aromatic substitutions which appeared in the 1960s, 1970s and 1980s [2].