Chapter 11. Pathways to Amyloid Fibril Formation: Partially Folded Intermediates in the Fibrillation of Natively Unfolded Proteins

  1. Jean D. Sipe
  1. Vladimir N. Uversky and
  2. Anthony L. Fink

Published Online: 23 JAN 2008

DOI: 10.1002/9783527619344.ch11

Amyloid Proteins: The Beta Sheet Conformation and Disease

Amyloid Proteins: The Beta Sheet Conformation and Disease

How to Cite

Uversky, V. N. and Fink, A. L. (2008) Pathways to Amyloid Fibril Formation: Partially Folded Intermediates in the Fibrillation of Natively Unfolded Proteins, in Amyloid Proteins: The Beta Sheet Conformation and Disease (ed J. D. Sipe), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619344.ch11

Editor Information

  1. 8406 North Brook Lane, Bethesda, MD 20814-2615, USA

Publication History

  1. Published Online: 23 JAN 2008
  2. Published Print: 26 JUL 2005

ISBN Information

Print ISBN: 9783527310722

Online ISBN: 9783527619344

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Keywords:

  • fibrillation;
  • amyloidogenic polypeptides;
  • neurodegenerative disorders;
  • tau protein;
  • prion diseases

Summary

This chapter contains sections titled:

  • Introduction

  • Molecular Mechanisms of Amyloid Fibril Formation by a Natively Unfolded Protein: αSynuclein

  • Fibrillogenesis of Natively Unfolded Proteins Requires Partial Folding

  • Fibrillation of Proteins Unrelated to Conformational Disease

  • Conclusions