Chapter 36. The Molecular Basis of Predicting Druggability

  1. Prof. Dr. Thomas Lengauer
  1. Bissan Al-Lazikani,
  2. Anna Gaulton,
  3. Gaia Paolini,
  4. Jerry Lanfear,
  5. John Overington,
  6. Andrew Hopkins

Published Online: 5 FEB 2008

DOI: 10.1002/9783527619368.ch36

Book Title

Bioinformatics - From Genomes to Therapies

Bioinformatics - From Genomes to Therapies

Additional Information

How to Cite

Al-Lazikani, B., Gaulton, A., Paolini, G., Lanfear, J., Overington, J. and Hopkins, A. (2008) The Molecular Basis of Predicting Druggability, in Bioinformatics - From Genomes to Therapies (ed T. Lengauer), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619368.ch36

Editor Information

  1. Max-Planck-Institute for Informatics, Stuhlsatzenhausweg 85, 66123 Saarbrücken, Germany

Publication History

  1. Published Online: 5 FEB 2008
  2. Published Print: 11 JAN 2007

ISBN Information

Print ISBN: 9783527312788

Online ISBN: 9783527619368

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Keywords:

  • coworkers;
  • lampel;
  • inpharmatica;
  • inhibitory;
  • transmembrane

Summary

This chapter contains sections titled:

  • Introduction

  • Chemical Properties of Drugs, Leads and Tools

  • Molecular Recognition is the Basis for Druggability

  • Estimating the Size of the Druggable Genome

  • Homology-based Analysis of Drug Targets

  • Feature-based Druggability Prediction

  • Structure-based Druggability Analysis of Protein Data Base (PDB) Structures

  • How Many Drug Targets are Accessible to Protein Therapeutics?

  • Conclusions

  • References

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