Chapter 20. Skeletogenesis in Zebrafish Embryos (Danio rerio)

  1. Prof. Dr. Edmund Bäuerlein
  1. Shao-Jun Du

Published Online: 20 MAR 2008

DOI: 10.1002/9783527619443.ch20

Handbook of Biomineralization: Biological Aspects and Structure Formation

Handbook of Biomineralization: Biological Aspects and Structure Formation

How to Cite

Du, S.-J. (2007) Skeletogenesis in Zebrafish Embryos (Danio rerio), in Handbook of Biomineralization: Biological Aspects and Structure Formation (ed E. Bäuerlein), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619443.ch20

Editor Information

  1. Max-Planck-Institute for Biochemistry, Department of Membrane Biochemistry, Am Klopferspitz 18 A, 82152 Planegg, Germany

Publication History

  1. Published Online: 20 MAR 2008
  2. Published Print: 25 MAY 2007

ISBN Information

Print ISBN: 9783527316410

Online ISBN: 9783527619443

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Keywords:

  • zebrafish;
  • skeletogenesis;
  • skeleton;
  • bone;
  • cartilage;
  • fin;
  • osteogenesis;
  • pharyngeal arch;
  • mineralization

Summary

Zebrafish (Danio rerio) has recently become a popular model to study skeletogenesis because it provides a unique system for both easy developmental analyses and powerful genetic screening. The transparent nature of the zebrafish embryo enables convenient observation of cartilage and bone development at the microscopic level. Genetic screens have generated large numbers of valuable mutants with developmental defects in craniofacial, axial, and fin skeletons. This chapter focuses primarily on recent studies on skeletogenesis in zebrafish, which have taken advantage of the simple embryology and genetic tractability of zebrafish to dissect the cellular and molecular mechanisms underlying skeletal development in vertebrates.