Chapter 5. Osteoporosis and Osteopetrosis

  1. Prof. Dr. Edmund Bäuerlein
  1. Adele L. Boskey

Published Online: 20 MAR 2008

DOI: 10.1002/9783527619443.ch49

Handbook of Biomineralization: Biological Aspects and Structure Formation

Handbook of Biomineralization: Biological Aspects and Structure Formation

How to Cite

Boskey, A. L. (2007) Osteoporosis and Osteopetrosis, in Handbook of Biomineralization: Biological Aspects and Structure Formation (ed E. Bäuerlein), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619443.ch49

Editor Information

  1. Max-Planck-Institute for Biochemistry, Department of Membrane Biochemistry, Am Klopferspitz 18 A, 82152 Planegg, Germany

Publication History

  1. Published Online: 20 MAR 2008
  2. Published Print: 25 MAY 2007

ISBN Information

Print ISBN: 9783527316410

Online ISBN: 9783527619443

SEARCH

Keywords:

  • bone formation;
  • bone remodeling;
  • osteoporosis;
  • osteopetrosis;
  • FTIR microspectroscopy;
  • raman spectroscopy;
  • x-ray diffraction;
  • electron microscopy;
  • osteoclasts;
  • osteoblasts

Summary

Osteoporosis, a common bone disease which generally affects the elderly, and osteopetrosis, a much rarer disease which appears early in life, share features of defective osteoclast activity, abnormal osteoblast activity, increased tendency to fracture, and altered bone mechanical properties. These features in both cases are associated with geometric and material abnormalities. In this chapter we review these diseases, their molecular and cellular bases, and the mineral and matrix properties as determined by X-ray diffraction and vibrational spectroscopy of bone from humans and animals with these conditions. The features of animal models of each of these conditions are compared with the presentation in humans.