Chapter 8. Stimulation of Bone Growth on Implants by Integrin Ligands

  1. Prof. Dr. Edmund Bäuerlein
  1. Mónica López-García and
  2. Horst Kessler

Published Online: 20 MAR 2008

DOI: 10.1002/9783527619443.ch52

Handbook of Biomineralization: Biological Aspects and Structure Formation

Handbook of Biomineralization: Biological Aspects and Structure Formation

How to Cite

López-García, M. and Kessler, H. (2007) Stimulation of Bone Growth on Implants by Integrin Ligands, in Handbook of Biomineralization: Biological Aspects and Structure Formation (ed E. Bäuerlein), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619443.ch52

Editor Information

  1. Max-Planck-Institute for Biochemistry, Department of Membrane Biochemistry, Am Klopferspitz 18 A, 82152 Planegg, Germany

Publication History

  1. Published Online: 20 MAR 2008
  2. Published Print: 25 MAY 2007

ISBN Information

Print ISBN: 9783527316410

Online ISBN: 9783527619443

SEARCH

Keywords:

  • integrins;
  • RGD peptides;
  • cell adhesion;
  • surface coating;
  • implants;
  • osseointegration

Summary

A successful biointegration of orthopedic and craniofacial implants requires a strong mechanical interaction between the surface of the artificial material and the surrounding natural bone tissue. Osseointegration of implants is known to be a biological process that occurs by formation of new peri-implant bone in direct contact with the synthetic surface. Mimicking the physiological adhesion process of osteoblasts to the extracellular matrix (ECM), by coating of implant surfaces with specific cell-adhesive molecules, was proven to enhance osteoblast adhesion in vitro and to accelerate osseointegration of implants in vivo. Cell adhesion is mediated by integrins, a class of heterodimeric transmembrane cell receptors that bind selectively to different proteins of the ECM and transduce information to the nucleus through cytoplasmic signaling pathways. The pep-tide sequence Arg-Gly-Asp (RGD), is by far the most effective and extensively studied ligand to promote osteoblast adhesion and proliferation on implants through integrin stimulation. The biofunctionalization of different surfaces with RGD peptides and mimetics has resulted in major improvements in bone implant technology.