Chapter 17. Tissue Engineering of Teeth

  1. Prof. Dr. Edmund Bäuerlein
  1. Misako Nakashima

Published Online: 20 MAR 2008

DOI: 10.1002/9783527619443.ch61

Handbook of Biomineralization: Biological Aspects and Structure Formation

Handbook of Biomineralization: Biological Aspects and Structure Formation

How to Cite

Nakashima, M. (2007) Tissue Engineering of Teeth, in Handbook of Biomineralization: Biological Aspects and Structure Formation (ed E. Bäuerlein), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619443.ch61

Editor Information

  1. Max-Planck-Institute for Biochemistry, Department of Membrane Biochemistry, Am Klopferspitz 18 A, 82152 Planegg, Germany

Publication History

  1. Published Online: 20 MAR 2008
  2. Published Print: 25 MAY 2007

ISBN Information

Print ISBN: 9783527316410

Online ISBN: 9783527619443

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Keywords:

  • tissue engineering;
  • dentin regeneration;
  • pulp regeneration;
  • dental pulp stem/progenitor cells;
  • odontoblasts;
  • pulp exposure;
  • gene therapy;
  • cell therapy;
  • bone morphogenetic proteins;
  • scaffold

Summary

The ultimate goal of endodontics and operative dentistry is to retain metabolic function and to reconstitute the occlusal and aesthetic function of teeth. Dental pulp is critical in maintaining homeostasis of the teeth. Deep caries and pulpal exposure have been treated by pulp capping or pulp amputation to preserve pulp tissue, but with limited success. Recent advances in stem cell biology and gene therapy technology have provided the potential for pulp stem cells as treatment in the regeneration of dentin-pulp complexes after injury such as caries. A rational approach to the tissue engineering of dentin is based on the triad of: responding stem/progenitor cells; morphogenetic signals for tissue induction; and the extracellular matrix scaffold to optimize the cellular microenvironment. In this chapter we summarize a number of issues related to this triad, aimed at the tissue engineering of dentin-pulp complexes, as well as details of preclinical studies of gene therapy to harness pulp stem cells with a morphogenetic signal, and bone morphogenetic protein (BMP) for dentin/pulp regeneration. Recent advances in the bioengineering of whole teeth are also discussed.