Chapter 10. The Role of the Apoptosome in Apoptosis and Cancer Therapy

  1. Prof. Dr. Klaus-Michael Debatin and
  2. PD Dr. Simone Fulda
  1. Kelvin Cain

Published Online: 26 MAY 2008

DOI: 10.1002/9783527619665.ch10

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

How to Cite

Cain, K. (2008) The Role of the Apoptosome in Apoptosis and Cancer Therapy, in Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts (eds K.-M. Debatin and S. Fulda), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619665.ch10

Editor Information

  1. Universitätsklinik für Kinder-und Jugendmedizin, Eythstr. 24, 89075, Ulm

Publication History

  1. Published Online: 26 MAY 2008
  2. Published Print: 6 FEB 2006

ISBN Information

Print ISBN: 9783527312375

Online ISBN: 9783527619665

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Keywords:

  • apoptosome;
  • cytochrome c;
  • intracellular signal;
  • bax oligomers;
  • cancer therapy

Summary

This chapter contains sections titled:

  • Introduction

  • Cytochrome c: The Intracellular Signal for Apoptosome Formation

  • Domains of Apaf-1: The Building Block of the Apoptosome

  • Activation of Apaf-1 and Apoptosome Formation Requires Adenine Nucleotides and Cytochrome c

  • Assembly and Composition of the Apoptosome

  • The Apoptosome Processes and Activates Caspase-9 and the Effector Caspases

  • Physiological Mechanisms that Regulate the Apoptosome

  • Apaf-1 and Apoptosome Function are Essential for Embryonic Development

  • The Role of the Apoptosome in Cancer Therapy

  • Apoptosome and Caspase-independent Cell Death

  • The Effect of Small Molecules on Apoptosome Formation and Function

  • Is the Apoptosome a Good Target for Cancer Therapy?