Chapter 11. The Role of the Bcl-2 Protein Family in Tumorigenesis and Cancer Therapy

  1. Prof. Dr. Klaus-Michael Debatin and
  2. PD Dr. Simone Fulda
  1. Edwina Naik and
  2. Andreas Strasser

Published Online: 26 MAY 2008

DOI: 10.1002/9783527619665.ch11

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

How to Cite

Naik, E. and Strasser, A. (2006) The Role of the Bcl-2 Protein Family in Tumorigenesis and Cancer Therapy, in Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts (eds K.-M. Debatin and S. Fulda), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619665.ch11

Editor Information

  1. Universitätsklinik für Kinder-und Jugendmedizin, Eythstr. 24, 89075, Ulm

Publication History

  1. Published Online: 26 MAY 2008
  2. Published Print: 6 FEB 2006

ISBN Information

Print ISBN: 9783527312375

Online ISBN: 9783527619665

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Keywords:

  • tumorigenesis;
  • homeostasis;
  • apoptosis;
  • morphology;
  • leukemic cells

Summary

This chapter contains sections titled:

  • Introduction

  • Tools of the Trade:The Cell Death Machinery

  • The Bcl-2 Family of Proteins

  • Role of the Bcl-2 Protein Family Members in Tumorigenesis

  • Bcl-2 Family Members Regulate Apoptotic Responses to Anticancer Agents

  • Bcl-2 Family Members as Targets for Cancer Therapy

  • Conclusions and Future Directions