Chapter 12. Bax, Bak and Bid: Key Mediators of Apoptosis

  1. Prof. Dr. Klaus-Michael Debatin and
  2. PD Dr. Simone Fulda
  1. Clare E. Dempsey,
  2. Darren L. Roberts and
  3. Caroline Dive

Published Online: 26 MAY 2008

DOI: 10.1002/9783527619665.ch12

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

How to Cite

Dempsey, C. E., Roberts, D. L. and Dive, C. (2006) Bax, Bak and Bid: Key Mediators of Apoptosis, in Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts (eds K.-M. Debatin and S. Fulda), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619665.ch12

Editor Information

  1. Universitätsklinik für Kinder-und Jugendmedizin, Eythstr. 24, 89075, Ulm

Publication History

  1. Published Online: 26 MAY 2008
  2. Published Print: 6 FEB 2006

ISBN Information

Print ISBN: 9783527312375

Online ISBN: 9783527619665

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Keywords:

  • metabolism;
  • redundancy;
  • fission;
  • cytosol;
  • liposomes

Summary

This chapter contains sections titled:

  • The Intrinsic Pathway of Apoptosis

  • Mechanism of Mitochondrial Killing

  • The Bcl-2 Family

  • Multidomain Proapoptotic Proteins Bax and Bak

  • Release of Mitochondrial Cytochrome c by Bcl-2 Family Proteins

  • BH3-only Bcl-2 Proteins

  • BH3-only Bcl-2 Proteins

  • A BH3-only Protein, Bid, That Can Interact with Both Pro- and Antiapoptotic Proteins

  • Functional Interactions between BH3-only Proteins and Multidomain Bcl-2 Proteins

  • Regulation of Bid

  • The Physiological Role of Bid

  • Full-length Bid versus tc Bid

  • Mechanisms by which Bid Causes Cytochrome c Release

  • Are Mitochondria Actually Required for Apoptosis?

  • Bid, Bax and Bak-Localization and Function at other Intracellular Organelles

  • Splice Variants of Bax, Bak and Bid

  • Bax, Bak and Bid in Cancer

  • Therapeutic Opportunities