Chapter 17. Cell Survival Signaling through Phosphoinositide 3-kinase and Protein Kinase B

  1. Prof. Dr. Klaus-Michael Debatin and
  2. PD Dr. Simone Fulda
  1. Michael P. Scheid and
  2. James R. Woodgett

Published Online: 26 MAY 2008

DOI: 10.1002/9783527619665.ch17

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

How to Cite

Scheid, M. P. and Woodgett, J. R. (2006) Cell Survival Signaling through Phosphoinositide 3-kinase and Protein Kinase B, in Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts (eds K.-M. Debatin and S. Fulda), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619665.ch17

Editor Information

  1. Universitätsklinik für Kinder-und Jugendmedizin, Eythstr. 24, 89075, Ulm

Publication History

  1. Published Online: 26 MAY 2008
  2. Published Print: 6 FEB 2006

ISBN Information

Print ISBN: 9783527312375

Online ISBN: 9783527619665

SEARCH

Keywords:

  • cell survival;
  • cancer lesion;
  • drosophila;
  • rapamycin;
  • glucose metabolism

Summary

This chapter contains sections titled:

  • Introduction

  • PKB: A Member of the “AGC” Kinase Subfamily

  • DNA-dependent Protein Kinase (DNA-PK) is a PKB Kinase

  • Mammalian Target of Rapamycin (mTOR)- Another PKB Kinase

  • Non-PIKK PKB regulators

  • PKB Substrates Involved in Apoptosis

  • Cell Cycle Progression is Controlled by PI3K-PKB

  • PI3K- PKB Effects on Glucose Metabolism

  • PKB Inhibits Transforming Growth Factor (TGF)-β Signaling

  • Death and Survival by PKB in Neuronal Pathologies

  • Conclusions