Chapter 2. The TRAIL Receptor-Ligand System: Biochemistry of Apoptosis Induction, Therapeutic Potential for Cancer Treatment and Physiological Function

  1. Prof. Dr. Klaus-Michael Debatin and
  2. PD Dr. Simone Fulda
  1. Henning Walczak,
  2. Ronald Koschny,
  3. Daniela Willen,
  4. Manuela B. Schader,
  5. Jaromir Sykora,
  6. Tom M. Ganten and
  7. Tobias L. Haas

Published Online: 26 MAY 2008

DOI: 10.1002/9783527619665.ch2

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

How to Cite

Walczak, H., Koschny, R., Willen, D., Schader, M. B., Sykora, J., Ganten, T. M. and Haas, T. L. (2006) The TRAIL Receptor-Ligand System: Biochemistry of Apoptosis Induction, Therapeutic Potential for Cancer Treatment and Physiological Function, in Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts (eds K.-M. Debatin and S. Fulda), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619665.ch2

Editor Information

  1. Universitätsklinik für Kinder-und Jugendmedizin, Eythstr. 24, 89075, Ulm

Publication History

  1. Published Online: 26 MAY 2008
  2. Published Print: 6 FEB 2006

ISBN Information

Print ISBN: 9783527312375

Online ISBN: 9783527619665

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Keywords:

  • biochemistry;
  • physiological function;
  • signaling;
  • tumor tissue;
  • genetic aberrations

Summary

This chapter contains sections titled:

  • Introduction

  • The TRAIL-TRAIL-Receptor System

  • TRAIL in Cancer Therapy-Clinical Applications and Safety

  • The Physiological Role of the TRAIL System

  • Concluding Remarks