Chapter 21. RB and Cancer

  1. Prof. Dr. Klaus-Michael Debatin and
  2. PD Dr. Simone Fulda
  1. B. Nelson Chau,
  2. Jacqueline Bergseid and
  3. Jean Y. J. Wang

Published Online: 26 MAY 2008

DOI: 10.1002/9783527619665.ch21

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

How to Cite

Chau, B. N., Bergseid, J. and Wang, J. Y. J. (2006) RB and Cancer, in Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts (eds K.-M. Debatin and S. Fulda), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619665.ch21

Editor Information

  1. Universitätsklinik für Kinder-und Jugendmedizin, Eythstr. 24, 89075, Ulm

Publication History

  1. Published Online: 26 MAY 2008
  2. Published Print: 6 FEB 2006

ISBN Information

Print ISBN: 9783527312375

Online ISBN: 9783527619665

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Keywords:

  • cancer;
  • retinoblastoma;
  • transcription regulation;
  • phosphorylation;
  • embryonic development

Summary

This chapter contains sections titled:

  • Introduction

  • RB: A Tissue-specific Tumor-suppressor Gene

  • The RB Gene Product

  • Mechanism of Transcription Regulation by RB

  • Regulation of RB by Phosphorylation

  • Biological Functions of RB Deduced from Mouse Genetic Studies

  • RB-negative Cancer Cells are Hypersensitive to Chemotherapeutics

  • Caspase-resistant RB Protects Against TNF-induced Apoptosis

  • Two Models for the Antiapoptotic Function of RB

  • Apoptotic Defects Accompany RB Loss in Tumor Development

  • Enhanced Phosphorylation of RB in Sporadic Cancer

  • Upregulation of RB in Sporadic Human Cancer Cells

  • Summary and Future Prospects