Chapter 22. Calcium Signaling in Apoptosis

  1. Prof. Dr. Klaus-Michael Debatin and
  2. PD Dr. Simone Fulda
  1. Sten Orrenius and
  2. Boris Zhivotovsky

Published Online: 26 MAY 2008

DOI: 10.1002/9783527619665.ch22

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

How to Cite

Orrenius, S. and Zhivotovsky, B. (2006) Calcium Signaling in Apoptosis, in Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts (eds K.-M. Debatin and S. Fulda), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619665.ch22

Editor Information

  1. Universitätsklinik für Kinder-und Jugendmedizin, Eythstr. 24, 89075, Ulm

Publication History

  1. Published Online: 26 MAY 2008
  2. Published Print: 6 FEB 2006

ISBN Information

Print ISBN: 9783527312375

Online ISBN: 9783527619665

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Keywords:

  • necrotic cell;
  • sarcoplasmic reticulum;
  • permeabilization;
  • oligomerization;
  • cytochrome c

Summary

This chapter contains sections titled:

  • Introduction

  • Major Forms of Cell Death

  • The Regulation of Intracellular Ca2+ Compartmentalization

  • Ca2+-activated Effector Mechanisms

  • Crosstalk between Caspases and Calpains in Regulation of Cell Death

  • Caspases, Calpain and Intracellular Ion Homeostasis

  • Effects of Bcl-2 Family Proteins on ER Ca2+ Storage

  • Ca2+ and the Phagocytosis of Apoptotic Cells

  • Calcium and Apoptosis in Cancer Cells

  • Conclusions