Chapter 26. Mouse Models in Cancer Research

  1. Prof. Dr. Klaus-Michael Debatin and
  2. PD Dr. Simone Fulda
  1. Soyoung Lee and
  2. Clemens A. Schmitt

Published Online: 26 MAY 2008

DOI: 10.1002/9783527619665.ch26

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

How to Cite

Lee, S. and Schmitt, C. A. (2006) Mouse Models in Cancer Research, in Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts (eds K.-M. Debatin and S. Fulda), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619665.ch26

Editor Information

  1. Universitätsklinik für Kinder-und Jugendmedizin, Eythstr. 24, 89075, Ulm

Publication History

  1. Published Online: 26 MAY 2008
  2. Published Print: 6 FEB 2006

ISBN Information

Print ISBN: 9783527312375

Online ISBN: 9783527619665

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Keywords:

  • mouse models;
  • orthotopic models;
  • transgenic mice;
  • knudson hypothesis;
  • cellular senescence

Summary

This chapter contains sections titled:

  • Introduction

  • No All-in-one Models Anymore

  • Mouse Models are Model Systems in Mice

  • Genetic Engineering of the Model Mouse

  • Mouse Models to Exploit Treatment Sensitivity of Cancer

  • Modeling Temporal and Spatial Complexities

  • Imaging in Mouse Models

  • Mouse Models as Complex Reporter Systems

  • Mouse Models for Genetic Screenings

  • Mice and Men … and Worms, Flies, Fish and Yeast

  • Mice and the Web