Chapter 31. Apoptosis Induced by DNA-damaging Agents

  1. Prof. Dr. Klaus-Michael Debatin and
  2. PD Dr. Simone Fulda
  1. Bernd Kaina and
  2. Wynand Roos

Published Online: 26 MAY 2008

DOI: 10.1002/9783527619665.ch31

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

How to Cite

Kaina, B. and Roos, W. (2008) Apoptosis Induced by DNA-damaging Agents, in Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts (eds K.-M. Debatin and S. Fulda), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619665.ch31

Editor Information

  1. Universitätsklinik für Kinder-und Jugendmedizin, Eythstr. 24, 89075, Ulm

Publication History

  1. Published Online: 26 MAY 2008
  2. Published Print: 6 FEB 2006

ISBN Information

Print ISBN: 9783527312375

Online ISBN: 9783527619665

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Keywords:

  • genotoxic stress;
  • apoptosis;
  • actinomycin D;
  • telangiectasia;
  • doxorubicin

Summary

This chapter contains sections titled:

  • Introduction

  • Evidence that DNA Damage Triggers Apoptosis:Response of DNA Repair-defective Cells

  • MGMT-and MMR-deficient (Tolerant) Cells: Evidence for Apoptosis Triggered by the Specific Lesion O6MeG

  • Apoptosis in BER Mutants

  • Apoptosis in NER Mutants

  • Apoptosis Triggered by DNA Incorporated Gancyclovir (GCV)

  • Are DNA DSBs the Ultimate Trigger of Apoptosis?

  • Role of DRs in DNA Damage-triggered Apoptosis

  • The Ataxia Telangiectasia Mutated Protein ATM and its related Protein ATR in Chk/p53 Signaling

  • A Dual Role for p53 in Apoptosis

  • Role of Caspase-2 in DNA Damage-induced Apoptosis

  • Immediate Early cellular Responses: Fos/AP-1

  • Agent Specificity in the Induction of Apoptosis: Effect of Topo Inhibitors

  • Conclusions