Chapter 38. Targeting the Phosphoinositide-3-kinase/Akt/Mammalian Target of Rapamycin Pathway

  1. Prof. Dr. Klaus-Michael Debatin and
  2. PD Dr. Simone Fulda
  1. Courtney A. Granville,
  2. Regan M. Memmott,
  3. Joell J. Gills and
  4. Phillip A. Dennis

Published Online: 26 MAY 2008

DOI: 10.1002/9783527619665.ch38

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

How to Cite

Granville, C. A., Memmott, R. M., Gills, J. J. and Dennis, P. A. (2006) Targeting the Phosphoinositide-3-kinase/Akt/Mammalian Target of Rapamycin Pathway, in Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts (eds K.-M. Debatin and S. Fulda), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619665.ch38

Editor Information

  1. Universitätsklinik für Kinder-und Jugendmedizin, Eythstr. 24, 89075, Ulm

Publication History

  1. Published Online: 26 MAY 2008
  2. Published Print: 6 FEB 2006

ISBN Information

Print ISBN: 9783527312375

Online ISBN: 9783527619665

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Keywords:

  • rapamycin;
  • phosphorylation;
  • n-terminal kinase;
  • immunohistochemical;
  • rhabdomyosarcoma

Summary

This chapter contains sections titled:

  • Regulation and Function of the Phosphoinositide-3-kinase (PI3K)/Akt/Mammalian Target of Rapamycin (mTOR)Pathway

  • The PI3K/Akt/mTOR Pathway in Established Cancer

  • Inhibition of PI3K/Akt/mTOR for Cancer Therapy

  • Considerations in Developing Inhibitors of the PI3K/Akt/mTOR Pathway

  • Summary