Chapter 6. Role of Mitochondrial Proteins in Apoptosis

  1. Prof. Dr. Klaus-Michael Debatin and
  2. PD Dr. Simone Fulda
  1. Xavier Saelens,
  2. Nele Festjens,
  3. Lieselotte Vande Walle and
  4. Peter Vandenabeele

Published Online: 26 MAY 2008

DOI: 10.1002/9783527619665.ch6

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

How to Cite

Saelens, X., Festjens, N., Vande Walle, L. and Vandenabeele, P. (2006) Role of Mitochondrial Proteins in Apoptosis, in Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts (eds K.-M. Debatin and S. Fulda), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619665.ch6

Editor Information

  1. Universitätsklinik für Kinder-und Jugendmedizin, Eythstr. 24, 89075, Ulm

Publication History

  1. Published Online: 26 MAY 2008
  2. Published Print: 6 FEB 2006

ISBN Information

Print ISBN: 9783527312375

Online ISBN: 9783527619665

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Keywords:

  • mitochondrial proteins;
  • apoptosis;
  • cytotoxic stresses;
  • chemotherapeutic drugs;
  • cytochrome c

Summary

This chapter contains sections titled:

  • Introduction

  • Bcl-2 Family Proteins and Mitochondrial Membrane Permeabilization

  • Mutations in the Intrinsic Apoptotic Pathway Contributing to Cancer

  • Cytochrome c

  • Cytochrome c Release: A Point of No Return?

  • IAP Inhibition by Mitochondrial Proteins

  • Other Mitochondrial Factors Released During Apoptosis

  • Conclusions and Perspectives