Chapter 8. Apoptosis-inducing Factor

  1. Prof. Dr. Klaus-Michael Debatin and
  2. PD Dr. Simone Fulda
  1. Nicola Vahsen and
  2. Guido Kroemer

Published Online: 26 MAY 2008

DOI: 10.1002/9783527619665.ch8

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

How to Cite

Vahsen, N. and Kroemer, G. (2006) Apoptosis-inducing Factor, in Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts (eds K.-M. Debatin and S. Fulda), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619665.ch8

Editor Information

  1. Universitätsklinik für Kinder-und Jugendmedizin, Eythstr. 24, 89075, Ulm

Publication History

  1. Published Online: 26 MAY 2008
  2. Published Print: 6 FEB 2006

ISBN Information

Print ISBN: 9783527312375

Online ISBN: 9783527619665

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Keywords:

  • apoptosis-inducing factor;
  • multifunctional protein;
  • localization;
  • isoforms;
  • nonmammalian orthologs;
  • cell-free systems

Summary

This chapter contains sections titled:

  • Introduction

  • AIF Expression, Structure and Localization

  • The Apoptotic Function

  • AIF Translocation

  • How Does AIF Exert its Effect on DNA?

  • The Vital Functions

  • AIF in Disease

  • Concluding Remarks