Chapter 9. Caspases: Agents of Defense and Destruction

  1. Prof. Dr. Klaus-Michael Debatin and
  2. PD Dr. Simone Fulda
  1. Colin Adrain and
  2. Seamus J. Martin

Published Online: 26 MAY 2008

DOI: 10.1002/9783527619665.ch9

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts

How to Cite

Adrain, C. and Martin, S. J. (2006) Caspases: Agents of Defense and Destruction, in Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts (eds K.-M. Debatin and S. Fulda), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619665.ch9

Editor Information

  1. Universitätsklinik für Kinder-und Jugendmedizin, Eythstr. 24, 89075, Ulm

Publication History

  1. Published Online: 26 MAY 2008
  2. Published Print: 6 FEB 2006

ISBN Information

Print ISBN: 9783527312375

Online ISBN: 9783527619665

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Keywords:

  • caspases;
  • proteolytic enzymes;
  • drosophila;
  • biochemical mechanisms;
  • granzyme B

Summary

This chapter contains sections titled:

  • Introduction

  • Caspases: Ubiquitous Mediators of Apoptotic Cell Death…And More

  • Caspase Structure and Classification

  • Catalytic Properties of Caspases

  • Biochemical Mechanisms

  • Pathways to Caspase Activation

  • Caspase Substrates

  • Physiological Roles of Caspases in Apoptosis and Inflammation

  • Deregulation of Caspases in Cancer

  • Harnessing Caspase Activation in Anticancer Therapy