Chapter 54. Crosspresentation and Loading of Tumor Antigens for Dendritic Cell Vaccination against Cancer

  1. PD. Dr. Manfred B. Lutz1,
  2. Prof. Dr. Nikolaus Romani2 and
  3. Prof. Dr. Alexander Steinkasserer1
  1. Madhav V. Dhodapkar

Published Online: 26 MAR 2008

DOI: 10.1002/9783527619696.ch54

Handbook of Dendritic Cells: Biology, Diseases, and Therapies

Handbook of Dendritic Cells: Biology, Diseases, and Therapies

How to Cite

Dhodapkar, M. V. (2006) Crosspresentation and Loading of Tumor Antigens for Dendritic Cell Vaccination against Cancer, in Handbook of Dendritic Cells: Biology, Diseases, and Therapies (eds M. B. Lutz, N. Romani and A. Steinkasserer), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619696.ch54

Editor Information

  1. 1

    Department of Dermatology, University Hospital of Erlangen, Hartmannstr. 14, 91052 Erlangen, Germany

  2. 2

    Department of Dermatology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Germany

Publication History

  1. Published Online: 26 MAR 2008
  2. Published Print: 6 FEB 2006

ISBN Information

Print ISBN: 9783527311095

Online ISBN: 9783527619696

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Keywords:

  • crosspresentation;
  • tumor antigens;
  • immunotherapy;
  • dying cells;
  • pathogens

Summary

This chapter contains sections titled:

  • Approaches to Antigen Loading for Dendritic-cell-mediated Immunotherapy

  • Importance of Receptor-mediated Uptake to Crosspresentation

  • Uptake of Dying Cells

  • Uptake of Immune Complexes and Opsonized Pathogens and Tumor Cells

  • Uptake of Heat Shock Protein -Peptide Complexes

  • Exosomes as Sources of Multiple Tumor Antigens

  • Role of C-type Lectin Receptors

  • Other Routes of Antigen Entry for Crosspresentation

  • Processing of the Antigenic Cargo

  • Nature of the Antigenic Cargo

  • Regulation of Crosspresentation during Dendritic Cell Maturation

  • Role of Dendritic Cell Subsets in Crosspresentation

  • Some Approaches to Improve Antigen Loading of Dendritic Cells for Clinical Vaccination

  • Concluding Remarks