Chapter 97. Permeability of Silicone-Water Interfaces in Water-in-Oil Emulsions

  1. Prof. Dr. Norbert Auner2 and
  2. Prof. Dr. Johann Weis3
  1. Michael A. Brook,
  2. Paul Zelisko and
  3. Meaghan Walsh

Published Online: 5 MAY 2008

DOI: 10.1002/9783527619924.ch97

Organosilicon Chemistry V: From Molecules to Materials

Organosilicon Chemistry V: From Molecules to Materials

How to Cite

Brook, M. A., Zelisko, P. and Walsh, M. (2003) Permeability of Silicone-Water Interfaces in Water-in-Oil Emulsions, in Organosilicon Chemistry V: From Molecules to Materials (eds N. Auner and J. Weis), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619924.ch97

Editor Information

  1. 2

    Department of Inorganic Chemistry, University of Frankfurt, Marie-Curie-Straße 11, 60439 Frankfurt am Main, Germany

  2. 3

    Consortium of Electrochemical Industry GmbH, Zielstattstraße 20, 81379 Munich, Germany

Author Information

  1. Department of Chemistry, McMaster University 1280 Main St. W., Hamilton, Ontario, Canada L8S 4M1 Tel.: +1 905 525 9140 ext. 23483 — Fax: +1 905 522 2509

Publication History

  1. Published Online: 5 MAY 2008
  2. Published Print: 26 SEP 2003

ISBN Information

Print ISBN: 9783527306701

Online ISBN: 9783527619924

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Keywords:

  • water-in-silicone oil emulsion;
  • enzyme stability;
  • protein release

Summary

Water-in-silicone oil emulsions, stabilized by silicone-polyether surfactants, are marginally permeable to polar, but uncharged, molecules such as phenolphthalein and crystal violet. However, charged compounds, including these compounds in basic and acidic pH regimes respectively, and proteins transfer much less readily from the internal water phase to external bulk water. Transfer experiments were followed colorimetrically. These experiments shed light on the possible mechanisms by which proteins may be released from these emulsions in bioactive form: simple breaking of the emulsion does not appear to be the mechanism of action.