35. Synthetic Access to Epothilones-Natural Products with Extraordinary Anticancer Activity

  1. Prof. Dr. Hans-Günther Schmalz
  1. Ludger A. Wessjohann and
  2. Günther Scheid

Published Online: 4 MAR 2008

DOI: 10.1002/9783527619979.ch35

Organic Synthesis Highlights IV

Organic Synthesis Highlights IV

How to Cite

Wessjohann, L. A. and Scheid, G. (2008) Synthetic Access to Epothilones-Natural Products with Extraordinary Anticancer Activity, in Organic Synthesis Highlights IV (ed H.-G. Schmalz), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619979.ch35

Editor Information

  1. Institut für Organische Chemie, der Universität zu Köln, Greinstrasse 4, D-50939 Köln, Germany

Author Information

  1. Bio-organic Chemistry, Vrije Universiteit, Amsterdam, The Netherlands

Publication History

  1. Published Online: 4 MAR 2008
  2. Published Print: 22 SEP 2000

ISBN Information

Print ISBN: 9783527299164

Online ISBN: 9783527619979

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Keywords:

  • antimitotic;
  • eleutherobine;
  • cytotoxic;
  • epothilones;
  • polyketide

Summary

This chapter contains sections titled:

  • General Aspects and Biology

  • Retrosynthetic Analysis

  • Macrocyclization and Epoxidation

  • Macrolactonization

  • Synthesis of the Thiazole Fragment A

  • Synthesis of the Aldol Fragments C and Aldol Reactions between C6 and C7

  • Derivatives of Epothilones: Syntheses and Structure-Activity Relationship