35. Synthetic Access to Epothilones-Natural Products with Extraordinary Anticancer Activity
- Prof. Dr. Hans-Günther Schmalz
Published Online: 4 MAR 2008
DOI: 10.1002/9783527619979.ch35
Copyright © 2000 WILEY-VCH Verlag GmbH
Book Title
Organic Synthesis Highlights IV
Additional Information
How to Cite
Wessjohann, L. A. and Scheid, G. (2008) Synthetic Access to Epothilones-Natural Products with Extraordinary Anticancer Activity, in Organic Synthesis Highlights IV (ed H.-G. Schmalz), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527619979.ch35
Editor Information
Institut für Organische Chemie, der Universität zu Köln, Greinstrasse 4, D-50939 Köln, Germany
Publication History
- Published Online: 4 MAR 2008
- Published Print: 22 SEP 2000
ISBN Information
Print ISBN: 9783527299164
Online ISBN: 9783527619979
- Summary
- Chapter
- References
Keywords:
- antimitotic;
- eleutherobine;
- cytotoxic;
- epothilones;
- polyketide
Summary
This chapter contains sections titled:
General Aspects and Biology
Retrosynthetic Analysis
Macrocyclization and Epoxidation
Macrolactonization
Synthesis of the Thiazole Fragment A
Synthesis of the Aldol Fragments C and Aldol Reactions between C6 and C7
Derivatives of Epothilones: Syntheses and Structure-Activity Relationship