18. Cell and Cell Debris Removal: Centrif Ugation and Crossflow Filtration

  1. H.-J. Rehm3,
  2. G. Reed4
  1. Rajiv V. Datar1,
  2. Carl-Gustaf Rosén2

Published Online: 26 MAY 2008

DOI: 10.1002/9783527620845.ch18

Book Title

Biotechnology: Bioprocessing, Volume 3, Second Edition

Biotechnology: Bioprocessing, Volume 3, Second Edition

Additional Information

How to Cite

Datar, R. V. and Rosén, C.-G. (2008) Cell and Cell Debris Removal: Centrif Ugation and Crossflow Filtration, in Biotechnology: Bioprocessing, Volume 3, Second Edition (eds H.-J. Rehm and G. Reed), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527620845.ch18

Editor Information

  1. 3

    Institut für Mikrobiologie, Universität, Münster, Corrensstraße 3, D-48149 Münster

  2. 4

    2131 N. Summit Ave., Apartment #304, Milwaukee, WI 53202-1347, USA

Author Information

  1. 1

    Glen Cove, NY 11542, USA

  2. 2

    Björnlunda, Sweden

Publication History

  1. Published Online: 26 MAY 2008
  2. Published Print: 28 OCT 1993

ISBN Information

Print ISBN: 9783527283132

Online ISBN: 9783527620845

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CHAPTER TOOLS

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Keywords:

  • biotechnological;
  • bioprocess;
  • electrokinetic separation;
  • centrifugal separators;
  • characteristics

Summary

This chapter contains sections titled:

  • Introduction

  • Elements of a Recovery Strategy

  • Characteristics of Centrifugal Separators

  • Principles of Centrifugation

  • Centrifuge Selection

  • Centrifuge Types and Their Applications

  • Centrifugal Separation of Cells and Cell Debris in a Model System

  • Industrial Application

  • Final Remarks on Centrifugation in Cell and Cell Debris Separation

  • Crossflow Filtration

  • Background and Theory

  • Incorporation of a Shear-Enhanced Diffusion Coefficient 12

  • Time-Dependent Flux Decline

  • Improving Crossflow Filtration Performance

  • Scale-Up

  • Comparative Economics

  • Conclusions

  • References

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