20. Issues of Large-Scale Plasmid DNA Manufacturing

  1. Prof. Dr. H.-J. Rehm2,
  2. Dr. G. Reed3
  1. Martin Schleef

Published Online: 20 MAR 2008

DOI: 10.1002/9783527620869.ch20

Book Title

Biotechnology: A: Recombinant Proteins, Monoclonal Antibodies, and Therapeutic Genes, Volume 5a, Second Edition

Biotechnology: A: Recombinant Proteins, Monoclonal Antibodies, and Therapeutic Genes, Volume 5a, Second Edition

Additional Information

How to Cite

Schleef, M. (2008) Issues of Large-Scale Plasmid DNA Manufacturing, in Biotechnology: A: Recombinant Proteins, Monoclonal Antibodies, and Therapeutic Genes, Volume 5a, Second Edition (eds H.-J. Rehm and G. Reed), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527620869.ch20

Editor Information

  1. 2

    Institut für Mikrobiologie, Universität Münster, Corrensstraße 3, D-48149 Münster, FRG

  2. 3

    1029 N. Jackson St., #501-A, Milwaukee, WI 53202-3226, USA

Author Information

  1. Hilden, Germany

Publication History

  1. Published Online: 20 MAR 2008
  2. Published Print: 26 NOV 1998

ISBN Information

Print ISBN: 9783527283156

Online ISBN: 9783527620869

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CHAPTER TOOLS

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Keywords:

  • eukaryotic cells;
  • immunogenic;
  • therapeutic;
  • specifications;
  • stability

Summary

The prelims comprise:

  • Introduction

  • Safety and Regulatory Aspects of Plasmid DNA Therapeutics

  • Basic Concepts for Plasmid Fermentation and Purification

  • The GMP Plasmid DNA Manufacturing Process

  • Pharmaceutical Requirements: GMP

  • The Future of Therapeutic Plasmid DNA

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