6. Advances in the Molecular Genetics of β-Lactam Antibiotic Biosynthesis

  1. Prof. Dr. H.-J. Rehm5 and
  2. Dr. G. Reed6
  1. Paul L. Skatrud1,
  2. Torsten Schwecke2,
  3. Henk Van Liempt3 and
  4. Matthew B. Tobin4

Published Online: 28 MAY 2008

DOI: 10.1002/9783527620890.ch6

Biotechnology: Products of Secondary Metabolism, Volume 7, Second Edition

Biotechnology: Products of Secondary Metabolism, Volume 7, Second Edition

How to Cite

Skatrud, P. L., Schwecke, T., Van Liempt, H. and Tobin, M. B. (1997) Advances in the Molecular Genetics of β-Lactam Antibiotic Biosynthesis, in Biotechnology: Products of Secondary Metabolism, Volume 7, Second Edition (eds H.-J. Rehm and G. Reed), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527620890.ch6

Editor Information

  1. 5

    Institut für Mikrobiologie, Universität, Münster, Corrensstraße 3, D-48149 Münster, FRG

  2. 6

    1914 N. Prospect Ave.,#61, Milwaukee, WI 53202-1401, USA

Author Information

  1. 1

    Indianapolis, IN, USA

  2. 2

    Cambridge, UK

  3. 3

    Bonn, Germany

  4. 4

    Indianapolis, IN, USA

Publication History

  1. Published Online: 28 MAY 2008
  2. Published Print: 24 APR 1997

ISBN Information

Print ISBN: 9783527283170

Online ISBN: 9783527620890

SEARCH

Keywords:

  • biosynthesis;
  • enzymes;
  • penicillin;
  • acyltransferase;
  • penicillin

Summary

The chapter contains sections titled:

  • Introduction

  • Organisms which Produce β-Lactam Antibiotics

  • Biosynthesis of β-Lactam Antibiotics

  • Development of Genetic Transformation Systems

  • Enzymes Involved in Penicillin Biosynthesis

  • Cloning of the Genes Involved in the Biosynthesis of Penicillin G, Cephalosporin C, and Cephamycin C

  • Clustering of β-Lactam Biosynthetic Genes

  • Compartmentalization of β-Lactam Biosynthetic Enzymes

  • Evolution of the β-Lactam Biosynthetic Pathway: The Horizontal Transfer Hypothesis

  • β-Lactam Antibiotics and Recombinant DNA Technology: Practical Applications

  • Regulation of β-Lactam Biosynthetic Gene Expression

  • Summary