Chapter 5. The Development of Herceptin®: Paving the Way for Individualized Cancer Therapy
- Dr. Jörg Knäblein
Published Online: 5 FEB 2008
DOI: 10.1002/9783527620982.ch5
Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA
Book Title
Modern Biopharmaceuticals: Design, Development and Optimization
Additional Information
How to Cite
Gutjahr, T. S. and Reinhardt, C. (2008) The Development of Herceptin®: Paving the Way for Individualized Cancer Therapy, in Modern Biopharmaceuticals: Design, Development and Optimization (ed J. Knäblein), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527620982.ch5
Editor Information
Head Microbiological Chemistry, Schering AG, Müllerstraße 178 13342 Berlin, Germany
Publication History
- Published Online: 5 FEB 2008
- Published Print: 25 AUG 2005
ISBN Information
Print ISBN: 9783527311842
Online ISBN: 9783527620982
- Summary
- Chapter
- References
Keywords:
- herceptin;
- hybridisation;
- paclitaxel;
- docetaxel;
- pivotal trial
Summary
This chapter contains sections titled:
Introduction
HER2
Herceptin Mechanism of Action and Effects on Cellular Processes
Preclinical Evidence
HER2 Testing as a Prerequisite for Herceptin Therapy: Development of Commercially Available and Validated Testing Methodologies
HER2 Testing Algorithm
Herceptin in Clinical Use
Future Prospects for Herceptin and other Targeted Therapies
Herceptin in Early Breast Cancer
Herceptin Adjuvant Trials
Conclusion