Chapter 6. Advances in the Molecular Genetics of β-Lactam Antibiotic Biosynthesis

  1. Prof. Dr. H.-J. Rehm5 and
  2. Dr. G. Reed6
  1. Paul L. Skatrud1,
  2. Torsten Schwecke2,
  3. Henk Van Liempt3 and
  4. Matthew B. Tobin4

Published Online: 7 MAY 2008

DOI: 10.1002/9783527620999.ch6g

Biotechnology Set, Second Edition

Biotechnology Set, Second Edition

How to Cite

Skatrud, P. L., Schwecke, T., Liempt, H. V. and Tobin, M. B. (2001) Advances in the Molecular Genetics of β-Lactam Antibiotic Biosynthesis, in Biotechnology Set, Second Edition (eds H.-J. Rehm and G. Reed), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527620999.ch6g

Editor Information

  1. 5

    Institut für Mikrobiologie, Universität Münster, Corrensstraße 3, D-4400 Münster

  2. 6

    2131 N. Summit Ave., Apartment #304, Milwaukee, WI 53202-1347, USA

Author Information

  1. 1

    Indianapolis, IN, USA

  2. 2

    Cambridge, UK

  3. 3

    Bonn, Germany

  4. 4

    Indianapolis, IN, USA

Publication History

  1. Published Online: 7 MAY 2008
  2. Published Print: 10 MAY 2001

ISBN Information

Print ISBN: 9783527257621

Online ISBN: 9783527620999



  • biosynthesis;
  • enzymes;
  • penicillin;
  • acyltransferase;
  • penicillin


The prelims comprise:

  • Introduction

  • Organisms which Produce β-Lactam Antibiotics

  • Biosynthesis of β-Lactam Antibiotics

  • Development of Genetic Transformation Systems

  • Enzymes Involved in Penicillin Biosynthesis

  • Cloning of the Genes Involved in the Biosynthesis of Penicillin G, Cephalosporin C, and Cephamycin C

  • Clustering of β-Lactam Biosynthetic Genes

  • Compartmentalization of β-Lactam Biosynthetic Enzymes

  • Evolution of the β-Lactam Biosynthetic Pathway: The Horizontal Transfer Hypothesis

  • β-Lactam Antibiotics and Recombinant DNA Technology: Practical Applications

  • Regulation of β-Lactam Biosynthetic Gene Expression

  • Summary