Chapter 7. Regioselective Oxidation of Aminosorbitol with Gluconobacter oxydans, Key Reaction in the Industrial 1-Deoxynojirimycin Synthesis

  1. Prof. Dr. H.-J. Rehm2 and
  2. Dr. G. Reed3
  1. Michael Schedel

Published Online: 7 MAY 2008

DOI: 10.1002/9783527620999.ch7i

Biotechnology Set, Second Edition

Biotechnology Set, Second Edition

How to Cite

Schedel, M. (2001) Regioselective Oxidation of Aminosorbitol with Gluconobacter oxydans, Key Reaction in the Industrial 1-Deoxynojirimycin Synthesis, in Biotechnology Set, Second Edition (eds H.-J. Rehm and G. Reed), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527620999.ch7i

Editor Information

  1. 2

    Institut für Mikrobiologie, Universität Münster, Corrensstraße 3, D-4400 Münster

  2. 3

    2131 N. Summit Ave., Apartment #304, Milwaukee, WI 53202-1347, USA

Author Information

  1. Wuppertal, Germany

Publication History

  1. Published Online: 7 MAY 2008
  2. Published Print: 10 MAY 2001

ISBN Information

Print ISBN: 9783527257621

Online ISBN: 9783527620999

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Keywords:

  • therapeutic;
  • enzyme;
  • inhibitor;
  • purification;
  • structurally

Summary

This chapter contains sections titled:

  • Introduction

  • Nojirimycin, 1-Deoxynojirimycin, and Miglitol

  • Three Routes to Produce 1-Deoxynojirimycin

  • Concept for a Combined Biotechnological-Chemical Synthesis of 1-Deoxynojirimycin

  • Oxidation of 1-Amino-1-Deoxy-D-Sorbitol by Gluconobacter oxydans

  • Biotransformation of N-Formyl-1-Amino-1-Deoxy-D-Sorbitol on the Industrial Scale

  • Fermentative Production of Gluconobacter oxydans Cells on the Industrial Scale

  • Conclusions and Outlook

  • References