Chapter 10. Developmental and Functional Consequences of Disturbed Energetic Communication in Brain of Creatine Kinase–Deficient Mice: Understanding CK's Role in the Fuelling of Behavior and Learning
- Prof. Valdur Saks4,5,6
Published Online: 22 NOV 2007
DOI: 10.1002/9783527621095.ch10
Copyright © 2007 Wiley-VCH Verlag GmbH & Co. KGaA
Book Title
Molecular System Bioenergetics: Energy for Life
Additional Information
How to Cite
Streijger, F., in 't Zandt, R., Renema, K. J., Oerlemans, F., Heerschap, A., Kuiper, J., Pluk, H., Jost, C., van der Zee, I. and Wieringa, B. (2007) Developmental and Functional Consequences of Disturbed Energetic Communication in Brain of Creatine Kinase–Deficient Mice: Understanding CK's Role in the Fuelling of Behavior and Learning, in Molecular System Bioenergetics: Energy for Life (ed V. Saks), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527621095.ch10
Editor Information
- 4
J. Fourier University, Laboratory of Bioenergetics, 2280 rue de la Piscine, 38041 Grenoble Cedex 9, France
- 5
Université Joseph Fourier, Bioénergétique Fondamentale et Appliquée, INSERM U884, BP 53X, 38041 Grenoble Cedex, France
- 6
National Institute of Chemical and Biological Physics, Laboratory of Bioenergetics, Akadeemia tee 23, 12618 Tallinn, Estonia
Publication History
- Published Online: 22 NOV 2007
- Published Print: 19 SEP 2007
ISBN Information
Print ISBN: 9783527317875
Online ISBN: 9783527621095
- Summary
- Chapter
- References
Keywords:
- molecular system bioenergetics;
- energy transfer networks;
- metabolic feedback regulation;
- modeling cellular energetics;
- creatine kinase–deficient mice;
- altered brain morphology;
- altered acoustic startle reflex response;
- hearing problems
Summary
This chapter contains sections titled:
Abstract
Use of Reverse Genetics to Study CK Function in Mouse Models
Expression Distribution of Brain-type CK mRNA and Protein Isoforms
CK− −/− − Mice Have Lower Body Weights
31P Magnetic Resonance Spectroscopy
Altered Brain Morphology: Involvement of the Intra-infra-pyramidal Mossy Fiber Field in CK− −/− − Mice
CK− −/− − Mice Show Impaired Spatial Learning in Wet and Dry Maze Tests
Cued Performance and Motor Coordination Are Normal in CK− −/− − Mice
CK− −/− − Mice Show Normal Open-field Exploration and Habituation
CK− −/− − Mice Show Abnormal Thermogenesis
Altered Acoustic Startle Reflex Response and Hearing Problems in CK− −/− − Mice
Pentylenetetrazole-induced Seizures Occur Later in B-CK− −/− − Mice
Conclusions and Future Outlook
References