Chapter 11. System Analysis of Cardiac Energetics–Excitation–Contraction Coupling: Integration of Mitochondrial Respiration, Phosphotransfer Pathways, Metabolic Pacing, and Substrate Supply in the Heart

  1. Prof. Valdur Saks6,7,8
  1. Prof. Valdur Saks6,7,8,
  2. Petras P. Dzeja1,
  3. Rita Guzun7,
  4. Mayis K. Aliev2,
  5. Marko Vendelin3,
  6. André Terzic4,
  7. Theo Wallimann5

Published Online: 22 NOV 2007

DOI: 10.1002/9783527621095.ch11

Book Title

Molecular System Bioenergetics: Energy for Life

Molecular System Bioenergetics: Energy for Life

Additional Information

How to Cite

Saks, V., Dzeja, P. P., Guzun, R., Aliev, M. K., Vendelin, M., Terzic, A. and Wallimann, T. (2007) System Analysis of Cardiac Energetics–Excitation–Contraction Coupling: Integration of Mitochondrial Respiration, Phosphotransfer Pathways, Metabolic Pacing, and Substrate Supply in the Heart, in Molecular System Bioenergetics: Energy for Life (ed V. Saks), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527621095.ch11

Editor Information

  1. 6

    J. Fourier University, Laboratory of Bioenergetics, 2280 rue de la Piscine, 38041 Grenoble Cedex 9, France

  2. 7

    Université Joseph Fourier, Bioénergétique Fondamentale et Appliquée, INSERM U884, BP 53X, 38041 Grenoble Cedex, France

  3. 8

    National Institute of Chemical and Biological Physics, Laboratory of Bioenergetics, Akadeemia tee 23, 12618 Tallinn, Estonia

Author Information

  1. 1

    Mayo Clinic College of Medicine, Departments of Medicine, Molecular Pharmacology, and Experimental Therapeutics, Division of Cardiovascular Diseases, 200 First Street SW, Rochester, MN 559095, USA

  2. 2

    Cardiology Research Center, Institute of Experimental Cardiology, Laboratory of Cardiac Pathology, 3rd Cherepkovskaya Street 15A, 121552 Moscow, Russia

  3. 3

    Tallinn University of Technology, Institute of Cybernetics, Laboratory of Systems Biology, Centre for Nonlinear Studies, Akadeemia tee 21, 12618 Tallinn, Estonia

  4. 4

    Mayo Clinic College of Medicine, Departments of Medicine, Medicinal Genetics, Molecular Pharmacology, and Experimental Therapeutics, 200 First Street SW, Rochester, MN 559095, USA

  5. 5

    ETH Zurich, Hoenggerberg, Institute of Cell Biology, HPM-D24, Schafmattstrasse 18, 8093 Zurich, Switzerland

  6. 6

    J. Fourier University, Laboratory of Bioenergetics, 2280 rue de la Piscine, 38041 Grenoble Cedex 9, France

  7. 7

    Université Joseph Fourier, Bioénergétique Fondamentale et Appliquée, INSERM U884, BP 53X, 38041 Grenoble Cedex, France

  8. 8

    National Institute of Chemical and Biological Physics, Laboratory of Bioenergetics, Akadeemia tee 23, 12618 Tallinn, Estonia

Publication History

  1. Published Online: 22 NOV 2007
  2. Published Print: 19 SEP 2007

ISBN Information

Print ISBN: 9783527317875

Online ISBN: 9783527621095

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Keywords:

  • molecular system bioenergetics;
  • energy transfer networks;
  • metabolic feedback regulation;
  • modeling cellular energetics;
  • cardiac energetics–excitation–contraction coupling;
  • integrated phosphotransfer;
  • synchronization;
  • electrical activities;
  • mechanical activities;
  • energy supply

Summary

This chapter contains sections titled:

  • Abstract

  • Introduction

  • Cardiac Energetics: The Frank-Starling Law and Its Metabolic Aspects

  • Excitation–Contraction Coupling and Calcium Metabolism

    • Excitation–Contraction Coupling

    • The Mitochondrial Calcium Cycle

  • Length-dependent Activation of Contractile System

  • Integrated Phosphotransfer and Signaling Networks in Regulation of Cellular Energy Homeostasis

    • Evidence for the Role of MtCK in Respiration Regulation in Permeabilized Cells in Situ

    • In Vivo Kinetic Evidence

    • Mathematical Modeling of Metabolic Feedback Regulation

  • “Metabolic Pacing”: Synchronization of Electrical and Mechanical Activities With Energy Supply

  • Metabolic Channeling Is Needed for Protection of the Cell from Functional Failure, Deleterious Effects of Calcium Overload, and Overproduction of Free Radicals

  • Molecular System Analysis of Integrated Mechanisms of Regulation of Fatty Acid and Glucose Oxidation

  • Concluding Remarks and Future Directions

  • References

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