Chapter 12. Principles of Mathematical Modeling and in Silico Studies of Integrated Cellular Energetics

  1. Prof. Valdur Saks3,4,5
  1. Marko Vendelin1,
  2. Prof. Valdur Saks3,4,5,
  3. Jüri Engelbrecht2

Published Online: 22 NOV 2007

DOI: 10.1002/9783527621095.ch12

Book Title

Molecular System Bioenergetics: Energy for Life

Molecular System Bioenergetics: Energy for Life

Additional Information

How to Cite

Vendelin, M., Saks, V. and Engelbrecht, J. (2007) Principles of Mathematical Modeling and in Silico Studies of Integrated Cellular Energetics, in Molecular System Bioenergetics: Energy for Life (ed V. Saks), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527621095.ch12

Editor Information

  1. 3

    J. Fourier University, Laboratory of Bioenergetics, 2280 rue de la Piscine, 38041 Grenoble Cedex 9, France

  2. 4

    Université Joseph Fourier, Bioénergétique Fondamentale et Appliquée, INSERM U884, BP 53X, 38041 Grenoble Cedex, France

  3. 5

    National Institute of Chemical and Biological Physics, Laboratory of Bioenergetics, Akadeemia tee 23, 12618 Tallinn, Estonia

Author Information

  1. 1

    Tallinn University of Technology, Institute of Cybernetics, Laboratory of Systems Biology, Centre for Nonlinear Studies, Akadeemia tee 21, 12618 Tallinn, Estonia

  2. 2

    Tallinn University of Technology, Institute of Cybernetics, Centre for Nonlinear Studies, Akadeemia tee 21, 12618 Tallinn, Estonia

  3. 3

    J. Fourier University, Laboratory of Bioenergetics, 2280 rue de la Piscine, 38041 Grenoble Cedex 9, France

  4. 4

    Université Joseph Fourier, Bioénergétique Fondamentale et Appliquée, INSERM U884, BP 53X, 38041 Grenoble Cedex, France

  5. 5

    National Institute of Chemical and Biological Physics, Laboratory of Bioenergetics, Akadeemia tee 23, 12618 Tallinn, Estonia

Publication History

  1. Published Online: 22 NOV 2007
  2. Published Print: 19 SEP 2007

ISBN Information

Print ISBN: 9783527317875

Online ISBN: 9783527621095

SEARCH

CHAPTER TOOLS

Get PDF (370K)

Keywords:

  • molecular system bioenergetics;
  • energy transfer networks;
  • metabolic feedback regulation;
  • modeling cellular energetics;
  • mathematical modeling;
  • in silico studies;
  • integrated cellular energetics;
  • modeling energy metabolism;
  • interaction between enzymes;
  • free energy profile

Summary

This chapter contains sections titled:

  • Abstract

  • Introduction

  • Mathematical Modeling

    • Basic Principles

    • Hierarchies

  • Modeling of Energy Metabolism

    • Enzyme Kinetics

    • Modeling of Intracellular Events

    • Thermodynamically Consistent Models

  • Interaction Between Enzymes

    • Phenomenological Modeling

    • Modeling the Mechanism of Functional Coupling Between MtCK and ANT

  • Linking Mechanics and Free Energy Profile

    • Terrell Hill Formalism

    • Actomyosin Interaction

  • Concluding Remarks

  • References

Get PDF (370K)