Chapter 13. Modeling Energetics of Ion Transport, Membrane Sensing and Systems Biology of the Heart

  1. Prof. Valdur Saks5,6,7
  1. Satoshi Matsuoka1,
  2. Hikari Jo2,
  3. Masanori Kuzumoto3,
  4. Ayako Takeuchi1,
  5. Ryuta Saito4,
  6. Akinori Noma1

Published Online: 22 NOV 2007

DOI: 10.1002/9783527621095.ch13

Book Title

Molecular System Bioenergetics: Energy for Life

Molecular System Bioenergetics: Energy for Life

Additional Information

How to Cite

Matsuoka, S., Jo, H., Kuzumoto, M., Takeuchi, A., Saito, R. and Noma, A. (2007) Modeling Energetics of Ion Transport, Membrane Sensing and Systems Biology of the Heart, in Molecular System Bioenergetics: Energy for Life (ed V. Saks), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527621095.ch13

Editor Information

  1. 5

    J. Fourier University, Laboratory of Bioenergetics, 2280 rue de la Piscine, 38041 Grenoble Cedex 9, France

  2. 6

    Université Joseph Fourier, Bioénergétique Fondamentale et Appliquée, INSERM U884, BP 53X, 38041 Grenoble Cedex, France

  3. 7

    National Institute of Chemical and Biological Physics, Laboratory of Bioenergetics, Akadeemia tee 23, 12618 Tallinn, Estonia

Author Information

  1. 1

    Kyoto University, Graduate School of Medicine, Department of Physiology and Biophysics, Yoshida-Konoe, Sakyo-ku, Kyoto 606-8501, Japan

  2. 2

    Kyoto University, Department of Physiology and Biophysics, Graduate School of Medicine, Yoshida-Konoe, Sakyo-ku, Kyoto 606-8501, Japan

  3. 3

    Discovery Research Laboratories, Shionogi & Co., Ltd., 12-4, Sagisu 5-chome, Fukushima-ku, Osaka 553-0002, Japan

  4. 4

    Discovery Technology Laboratory, Mitsubishi Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan

Publication History

  1. Published Online: 22 NOV 2007
  2. Published Print: 19 SEP 2007

ISBN Information

Print ISBN: 9783527317875

Online ISBN: 9783527621095

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Keywords:

  • molecular system bioenergetics;
  • energy transfer networks;
  • metabolic feedback regulation;
  • modeling cellular energetics;
  • modeling energetics of ion transport;
  • membrane sensing;
  • systems biology of heart;
  • modeling ATP-related systems;
  • Kyoto model;
  • Ca2+-dependent regulation;
  • mitochondria function

Summary

This chapter contains sections titled:

  • Abstract

  • Introduction

  • Modeling ATP-related Systems

    • Na+/K+-ATPase

    • SERCA and PMCA

    • Contraction

    • ATP-sensitive K+ Channel and L-type Ca2+ Channel

    • Mitochondrial Oxidative Phosphorylation

  • ATP Balance in the Kyoto Model

  • Feedback Control and Ca2+-dependent Regulation of Mitochondria Function

  • References

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