Chapter 15. Mitochondrial Medicine: The Central Role of Cellular Energetic Depression and Mitochondria in Cell Pathophysiology

  1. Prof. Valdur Saks5,6,7
  1. Enn Seppet1,
  2. Zemfira Gizatullina2,
  3. Sonata Trumbeckaite3,
  4. Stephan Zierz4,
  5. Frank Striggow2,
  6. Frank Norbert Gellerich2

Published Online: 22 NOV 2007

DOI: 10.1002/9783527621095.ch15

Book Title

Molecular System Bioenergetics: Energy for Life

Molecular System Bioenergetics: Energy for Life

Additional Information

How to Cite

Seppet, E., Gizatullina, Z., Trumbeckaite, S., Zierz, S., Striggow, F. and Gellerich, F. N. (2007) Mitochondrial Medicine: The Central Role of Cellular Energetic Depression and Mitochondria in Cell Pathophysiology, in Molecular System Bioenergetics: Energy for Life (ed V. Saks), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527621095.ch15

Editor Information

  1. 5

    J. Fourier University, Laboratory of Bioenergetics, 2280 rue de la Piscine, 38041 Grenoble Cedex 9, France

  2. 6

    Université Joseph Fourier, Bioénergétique Fondamentale et Appliquée, INSERM U884, BP 53X, 38041 Grenoble Cedex, France

  3. 7

    National Institute of Chemical and Biological Physics, Laboratory of Bioenergetics, Akadeemia tee 23, 12618 Tallinn, Estonia

Author Information

  1. 1

    University of Tartu, Department of Pathophysiology, 19 Ravila Street, 50411 Tartu, Estonia

  2. 2

    KeyNeurotek AG, ZENIT – Technology Park, Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany

  3. 3

    Kaunas University of Medicine, Institute for Biomedical Research, 4 Eiveniu Street, 50009 Kaunas, Lithuania

  4. 4

    Universität Halle/Wittenberg, Neurologische Klinik und Poliklinik der Martin-Luther-Universität, 06097 Halle/Saale, Germany

Publication History

  1. Published Online: 22 NOV 2007
  2. Published Print: 19 SEP 2007

ISBN Information

Print ISBN: 9783527317875

Online ISBN: 9783527621095

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Keywords:

  • applied molecular system bioenergetics;
  • mitochondrial medicine;
  • cellular energetic depression;
  • mitochondrial cell death;
  • involvement mitochondria aging;
  • involvement mitochondria disease;
  • mitochondrial dysfunction detection

Summary

This chapter contains sections titled:

  • Abstract

  • Introduction

  • The Concept and Molecular Mechanisms of Cellular Energetic Depression and Mitochondrial Cell Death

    • Interaction of Mitochondria and Sarco/Endoplasmic Reticulum in Regulation of Cytosolic Ca2+

    • Role of Altered Energy Compartmentation in Cellular Energetic Depression

  • Involvement of Mitochondria in Aging and Disease

    • Mitochondria and Aging

    • Mitochondria in Neurodegenerative Diseases

      • Huntington's Disease

      • Parkinson's Disease

      • Alzheimer's Disease

      • Hypoxia

      • Cancer

      • Inflammation

  • Detection of Mitochondrial Dysfunction by Multiple Substrate Inhibitor Titration and Application of Metabolic Control Analysis

  • References

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