Chapter 16. Tumor Cell Energetic Metabolome
- Prof. Valdur Saks3,4,5
Published Online: 22 NOV 2007
DOI: 10.1002/9783527621095.ch16
Copyright © 2007 Wiley-VCH Verlag GmbH & Co. KGaA
Book Title
Molecular System Bioenergetics: Energy for Life
Additional Information
How to Cite
Mazurek, S. (2007) Tumor Cell Energetic Metabolome, in Molecular System Bioenergetics: Energy for Life (ed V. Saks), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527621095.ch16
Editor Information
- 3
J. Fourier University, Laboratory of Bioenergetics, 2280 rue de la Piscine, 38041 Grenoble Cedex 9, France
- 4
Université Joseph Fourier, Bioénergétique Fondamentale et Appliquée, INSERM U884, BP 53X, 38041 Grenoble Cedex, France
- 5
National Institute of Chemical and Biological Physics, Laboratory of Bioenergetics, Akadeemia tee 23, 12618 Tallinn, Estonia
Publication History
- Published Online: 22 NOV 2007
- Published Print: 19 SEP 2007
ISBN Information
Print ISBN: 9783527317875
Online ISBN: 9783527621095
- Summary
- Chapter
- References
Keywords:
- applied molecular system bioenergetics;
- tumor cell energetic metabolome;
- Otto Warburg's Discovery;
- glycolysis;
- Regeneration of Cytosolic NAD+;
- glutaminolysis;
- AMP;
- tumor cell energetic metabolome;
- Tool for Tumor Diagnosis;
- Target for Therapy
Summary
This chapter contains sections titled:
Abstract
Introduction
Otto Warburg's Discovery
Glycolysis: A Bifunctional Pathway in Tumor Cells
Compartmentalization of Glycolysis in the Cytosol by the Glycolytic Enzyme Complex
Tumor Cell Characteristic Glycolytic Isoenzyme Profiles and Regulation Mechanisms
Influence of Transcription Factors and Oncoproteins
Regeneration of Cytosolic NAD+: An Achilles Heel in the Tumor Cell Energetic Metabolome
Lactate Dehydrogenase
Glycerol 3-P Shuttle
Malate–Aspartate Shuttle
Glutaminolysis: A Second Main Pillar for Energy Conversion in Tumor Cells
The Truncated Citric Acid Cycle
The Glutaminolytic Pathway
Energy Conversion in Glutaminolysis
Advantages and Disadvantages of Glutaminolysis
AMP: A Mediator Between Tumor Cell Energetic Metabolism and Cell Proliferation
The Tumor Cell Energetic Metabolome as a Tool for Tumor Diagnosis
The Tumor Cell Energetic Metabolome as a Target for Therapy
References