Chapter 18. A Systems Biology Perspective on Obesity and Type 2 Diabetes

  1. Prof. Valdur Saks6,7,8
  1. Jolita Ciapaite1,2,
  2. Stephan J. L. Bakker3,
  3. Robert J. Heine4,
  4. Klaas Krab2,
  5. Hans V. Westerhoff2,5

Published Online: 22 NOV 2007

DOI: 10.1002/9783527621095.ch18

Book Title

Molecular System Bioenergetics: Energy for Life

Molecular System Bioenergetics: Energy for Life

Additional Information

How to Cite

Ciapaite, J., Bakker, S. J. L., Heine, R. J., Krab, K. and Westerhoff, H. V. (2007) A Systems Biology Perspective on Obesity and Type 2 Diabetes, in Molecular System Bioenergetics: Energy for Life (ed V. Saks), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527621095.ch18

Editor Information

  1. 6

    J. Fourier University, Laboratory of Bioenergetics, 2280 rue de la Piscine, 38041 Grenoble Cedex 9, France

  2. 7

    Université Joseph Fourier, Bioénergétique Fondamentale et Appliquée, INSERM U884, BP 53X, 38041 Grenoble Cedex, France

  3. 8

    National Institute of Chemical and Biological Physics, Laboratory of Bioenergetics, Akadeemia tee 23, 12618 Tallinn, Estonia

Author Information

  1. 1

    Vytautas Magnus University, Faculty of Nature Sciences, Centre of Environmental Research, Vileikos 8, 44404 Kaunas, Lithuania

  2. 2

    VU University, Faculty of Earth and Life Sciences, Department of Molecular Cell Physiology, Institute for Molecular Cell Biology, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands

  3. 3

    University of Groningen and University Medical Center Groningen, Department of Internal Medicine, Hanzeplein 1, 9700 RB Groningen, The Netherlands

  4. 4

    VU University Medical Center, Department of Endocrinology, Institute for Cardiovascular Research, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands

  5. 5

    The University of Manchester, Manchester Centre for Integrative, Systems Biology, MIB, Sackville Street, Manchester M60 1QD, United Kingdom

Publication History

  1. Published Online: 22 NOV 2007
  2. Published Print: 19 SEP 2007

ISBN Information

Print ISBN: 9783527317875

Online ISBN: 9783527621095

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Keywords:

  • applied molecular system bioenergetics;
  • obesity;
  • type 2 diabetes;
  • glucose homeostasis;
  • fatty acid–induced insulin resistance;
  • fatty acid–induced β-cell dysfunction;
  • metabolic control analysis

Summary

This chapter contains sections titled:

  • Abstract

  • Introduction

  • Glucose Homeostasis

  • Obesity in Relation to Glucose Homeostasis

  • Fatty Acid–induced Insulin Resistance

  • Fatty Acid–induced β-cell Dysfunction

  • Type 2 Diabetes from the Systems Biology Point of View

  • Metabolic Control Analysis

    • Definitions of Metabolic Control Analysis

    • Theorems of Metabolic Control Analysis

    • Modular Metabolic Control Analysis

  • References

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