Chapter 2. Organization and Regulation of Mitochondrial Oxidative Phosphorylation

  1. Prof. Valdur Saks2,3,4
  1. Michel Rigoulet,
  2. Arnaud Mourier,
  3. Anne Devin

Published Online: 22 NOV 2007

DOI: 10.1002/9783527621095.ch2

Book Title

Molecular System Bioenergetics: Energy for Life

Molecular System Bioenergetics: Energy for Life

Additional Information

How to Cite

Rigoulet, M., Mourier, A. and Devin, A. (2007) Organization and Regulation of Mitochondrial Oxidative Phosphorylation, in Molecular System Bioenergetics: Energy for Life (ed V. Saks), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527621095.ch2

Editor Information

  1. 2

    J. Fourier University, Laboratory of Bioenergetics, 2280 rue de la Piscine, 38041 Grenoble Cedex 9, France

  2. 3

    Université Joseph Fourier, Bioénergétique Fondamentale et Appliquée, INSERM U884, BP 53X, 38041 Grenoble Cedex, France

  3. 4

    National Institute of Chemical and Biological Physics, Laboratory of Bioenergetics, Akadeemia tee 23, 12618 Tallinn, Estonia

Author Information

  1. Université de Bordeaux 2, Institut de Biochimie et de Génétique Cellulaires du CNRS, 1 Rue Camille Saint Saëns, 33077 Bordeaux Cedex, France

Publication History

  1. Published Online: 22 NOV 2007
  2. Published Print: 19 SEP 2007

ISBN Information

Print ISBN: 9783527317875

Online ISBN: 9783527621095

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Keywords:

  • molecular system bioenergetics organization;
  • regulation;
  • mitochondrial oxidative phosphorylation;
  • chemiosmotic theory;
  • energy waste;
  • proton pumps;
  • respiratory chain

Summary

This chapter contains sections titled:

  • Abstract

  • Introduction

  • Oxidative Phosphorylation and the Chemiosmotic Theory

  • The Various Mechanisms of Energy Waste

    • Passive Leak

    • Leak Catalyzed by Uncoupling Proteins

    • The Active Leak

    • The Slipping Mechanism

  • Mechanisms of Coupling in Proton Pumps

  • Oxidative Phosphorylation Control and Regulation

    • Metabolic Control Analysis

    • Regulations

      • Kinetic Regulation of Mitochondrial Oxidative Phosphorylation: Complex I Covalent cAMP-dependent Phosphorylation

      • Cytochrome Oxidase: An Example of Coordinate Regulation

  • Supramolecular Organization of the Respiratory Chain

    • Structural Data

      • ATP Synthase Organization

      • Respiratory Chain Supramolecular Organization

    • Functional Data

  • Conclusions

  • References

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