Chapter 3. Integrated and Organized Cellular Energetic Systems: Theories of Cell Energetics, Compartmentation, and Metabolic Channeling
- Prof. Valdur Saks2,3,4
Published Online: 22 NOV 2007
DOI: 10.1002/9783527621095.ch3
Copyright © 2007 Wiley-VCH Verlag GmbH & Co. KGaA
Book Title
Molecular System Bioenergetics: Energy for Life
Additional Information
How to Cite
Saks, V., Monge, C., Anmann, T. and Dzeja, P. P. (2007) Integrated and Organized Cellular Energetic Systems: Theories of Cell Energetics, Compartmentation, and Metabolic Channeling, in Molecular System Bioenergetics: Energy for Life (ed V. Saks), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527621095.ch3
Editor Information
- 2
J. Fourier University, Laboratory of Bioenergetics, 2280 rue de la Piscine, 38041 Grenoble Cedex 9, France
- 3
Université Joseph Fourier, Bioénergétique Fondamentale et Appliquée, INSERM U884, BP 53X, 38041 Grenoble Cedex, France
- 4
National Institute of Chemical and Biological Physics, Laboratory of Bioenergetics, Akadeemia tee 23, 12618 Tallinn, Estonia
Publication History
- Published Online: 22 NOV 2007
- Published Print: 19 SEP 2007
ISBN Information
Print ISBN: 9783527317875
Online ISBN: 9783527621095
- Summary
- Chapter
- References
Keywords:
- molecular system bioenergetics;
- biological oxidation;
- basic principles;
- organization;
- dynamics;
- cellular energetics;
- compartmentation;
- metabolic channeling
Summary
This chapter contains sections titled:
Abstract
Introduction
Theoretical Basis of Cellular Metabolism and Bioenergetics
Thermodynamic Laws, Energy Metabolism, and Cellular Organization
Chemical and Electrochemical Potentials: Energy of Transmembrane Transport and Metabolic Reactions
Non-equilibrium, Steady-state Conditions
Free Energy Changes and the Problem of Intracellular Organization of Metabolism
Macromolecular Crowding, Heterogeneity of Diffusion, Compartmentation, and Vectorial Metabolism
Heterogeneity of Intracellular Diffusion and Metabolic Channeling
Compartmentation Phenomenon and Vectorial Metabolism
Compartmentalized Energy Transfer and Metabolic Sensing
Compartmentation of Adenine Nucleotides in Cardiac Cells
Unitary (Modular) Organization of Energy Metabolism and Compartmentalized Energy Transfer in Cardiac Cells
Functional Coupling of Mitochondrial Creatine Kinase and Adenine Nucleotide Translocase
Kinetic Evidence of Functional Coupling
Thermodynamic Evidence of Functional Coupling
Heterogeneity of ADP Diffusion in Permeabilized Cells: Importance of Structural Organization
Evidence for the Importance of Functional Coupling for Cell Life
Myofibrillar Creatine Kinase
Membrane-bound Creatine Kinases and Membrane Energy Sensing
The Mechanism of Acute Contractile Failure of the Ischemic Heart
Creatine Kinase System in Brain Cells
Maxwell's Demon and Organized Cellular Metabolism
References