Chapter 4. On the Network Properties of Mitochondria

  1. Prof. Valdur Saks2,3,4
  1. Miguel A. Aon,
  2. Sonia Cortassa,
  3. Brian O'Rourke

Published Online: 22 NOV 2007

DOI: 10.1002/9783527621095.ch4

Molecular System Bioenergetics: Energy for Life

Molecular System Bioenergetics: Energy for Life

How to Cite

Aon, M. A., Cortassa, S. and O'Rourke, B. (2007) On the Network Properties of Mitochondria, in Molecular System Bioenergetics: Energy for Life (ed V. Saks), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527621095.ch4

Editor Information

  1. 2

    J. Fourier University, Laboratory of Bioenergetics, 2280 rue de la Piscine, 38041 Grenoble Cedex 9, France

  2. 3

    Université Joseph Fourier, Bioénergétique Fondamentale et Appliquée, INSERM U884, BP 53X, 38041 Grenoble Cedex, France

  3. 4

    National Institute of Chemical and Biological Physics, Laboratory of Bioenergetics, Akadeemia tee 23, 12618 Tallinn, Estonia

Author Information

  1. Johns Hopkins University, Institute of Molecular Cardiobiology, 720 Rutland Avenue, 1059 Ross Building, Baltimore, MD 21205, USA

Publication History

  1. Published Online: 22 NOV 2007
  2. Published Print: 19 SEP 2007

ISBN Information

Print ISBN: 9783527317875

Online ISBN: 9783527621095

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Keywords:

  • molecular system bioenergetics;
  • biological oxidation;
  • organization;
  • dynamics;
  • cellular energetics;
  • network properties mitochondria;
  • mitochondrial morphodynamics;
  • inner membrane ion channels;
  • outer membrane ion channels;
  • mitochondrial network dynamics;
  • intracellular signaling

Summary

This chapter contains sections titled:

  • Abstract

  • Introduction

    • Conceptual Issues About Networks

  • The Study of (Sub)Cellular Networks and the Emerging View of Cells as Dynamic Mass Energy Information Networks

  • Mitochondrial Morphodynamics

  • The Key Role of Inner and Outer Membrane Ion Channels on Mitochondrial Network Dynamics

  • Mitochondrial Network Behavior Associated with Intracellular Signaling

    • Mitochondria as Intracellular Timekeepers

  • Mitochondria as a Network of Coupled Oscillators

    • Spatial and Temporal Aspects of Synchronization

    • Mitochondrial Network Collapse and Scaling: A Cascade of Failures from the Bottom Up

  • Discussion

    • What Is the Contribution of the Network View of Mitochondrial Function?

    • Why a Network View of Mitochondria May Contribute to Understanding Aging and Illness

  • Concluding Remarks

  • References