Chapter 6. Mitochondrial VDAC and Its Complexes

  1. Prof. Valdur Saks2,3,4
  1. Dieter Brdiczka

Published Online: 22 NOV 2007

DOI: 10.1002/9783527621095.ch6

Book Title

Molecular System Bioenergetics: Energy for Life

Molecular System Bioenergetics: Energy for Life

Additional Information

How to Cite

Brdiczka, D. (2007) Mitochondrial VDAC and Its Complexes, in Molecular System Bioenergetics: Energy for Life (ed V. Saks), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527621095.ch6

Editor Information

  1. 2

    J. Fourier University, Laboratory of Bioenergetics, 2280 rue de la Piscine, 38041 Grenoble Cedex 9, France

  2. 3

    Université Joseph Fourier, Bioénergétique Fondamentale et Appliquée, INSERM U884, BP 53X, 38041 Grenoble Cedex, France

  3. 4

    National Institute of Chemical and Biological Physics, Laboratory of Bioenergetics, Akadeemia tee 23, 12618 Tallinn, Estonia

Author Information

  1. University of Konstanz, Faculty of Biology, Untere Bohlstrasse 45, 78465 Konstanz, Germany

Publication History

  1. Published Online: 22 NOV 2007
  2. Published Print: 19 SEP 2007

ISBN Information

Print ISBN: 9783527317875

Online ISBN: 9783527621095

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CHAPTER TOOLS

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Keywords:

  • molecular system bioenergetics;
  • energy transfer networks;
  • metabolic feedback regulation;
  • modeling cellular energetics;
  • mitochondrial VDAC;
  • VDAC complexes;
  • mitochondria;
  • apoptosis;
  • organizing kinases;
  • cytochrome c

Summary

This chapter contains sections titled:

  • Abstract

  • The Role of VDAC in Controlling the Interaction of Mitochondria with the Cytosol

  • Molecular Structure and Membrane Topology of VDAC

  • VDAC Conductance, Voltage Dependence, and Ion Selectivity

  • The Physiological Significance of VDAC Voltage Gating

  • VDAC Isoforms and Functions

  • Mitochondria and Apoptosis

  • VDAC and ANT May Form the Mitochondrial Permeability Transition Pore

  • Accessory MPT Pore Subunits

  • ANT Knockout Studies

  • The Role of VDAC in Organizing Kinases at the Mitochondrial Surface

  • Hexokinase–VDAC–ANT Complexes in Tumor Cells

  • Hexokinase as a Marker Enzyme of Contact Sites

  • VDAC–ANT Complexes

  • VDAC–ANT Complexes Contain Cytochrome c

  • VDAC Oligomerization and Cytochrome c Binding

  • Possible Function of Cytochrome c in the Contact Sites

  • Cholesterol and Cardiolipin Influence VDAC Structure and Function

  • The Importance of VDAC Complexes in Regulation of Energy Metabolism and Apoptosis

  • Suppression of Bax-dependent Cytochrome c Release and Permeability Transition by Hexokinase

  • Suppression of Permeability Transition and Cytochrome c Release by Mitochondrial Creatine Kinase

  • The General Importance of the Creatine Kinase System in Heart Performance

  • The Central Regulatory Role of ANT

  • References

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