Chapter 8. Integration of Adenylate Kinase and Glycolytic and Glycogenolytic Circuits in Cellular Energetics

  1. Prof. Valdur Saks4,5,6
  1. Petras P. Dzeja1,
  2. Susan Chung2,
  3. Andre Terzic3

Published Online: 22 NOV 2007

DOI: 10.1002/9783527621095.ch8

Book Title

Molecular System Bioenergetics: Energy for Life

Molecular System Bioenergetics: Energy for Life

Additional Information

How to Cite

Dzeja, P. P., Chung, S. and Terzic, A. (2007) Integration of Adenylate Kinase and Glycolytic and Glycogenolytic Circuits in Cellular Energetics, in Molecular System Bioenergetics: Energy for Life (ed V. Saks), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527621095.ch8

Editor Information

  1. 4

    J. Fourier University, Laboratory of Bioenergetics, 2280 rue de la Piscine, 38041 Grenoble Cedex 9, France

  2. 5

    Université Joseph Fourier, Bioénergétique Fondamentale et Appliquée, INSERM U884, BP 53X, 38041 Grenoble Cedex, France

  3. 6

    National Institute of Chemical and Biological Physics, Laboratory of Bioenergetics, Akadeemia tee 23, 12618 Tallinn, Estonia

Author Information

  1. 1

    Mayo Clinic College of Medicine, Departments of Medicine, Molecular Pharmacology, and Experimental Therapeutics, Division of Cardiovascular Diseases, 200 First Street SW, Rochester, MN 559095, USA

  2. 2

    Mayo Clinic College of Medicine, Departments of Biochemistry and Molecular Biology, 200 First Street SW, Rochester, MN 559095, USA

  3. 3

    Mayo Clinic College of Medicine, Departments of Medicine, Medicinal Genetics, Molecular Pharmacology, and Experimental Therapeutics, 200 First Street SW, Rochester, MN 559095, USA

Publication History

  1. Published Online: 22 NOV 2007
  2. Published Print: 19 SEP 2007

ISBN Information

Print ISBN: 9783527317875

Online ISBN: 9783527621095

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Keywords:

  • molecular system bioenergetics;
  • energy transfer networks;
  • metabolic feedback regulation;
  • modeling cellular energetics;
  • adenylate kinase;
  • glycolytic circuits;
  • glycogenolytic circuits;
  • AMP metabolic signaling;
  • phosphotransfer circuits;
  • metabolite shuttles

Summary

This chapter contains sections titled:

  • Abstract

  • Introduction

  • The Adenylate Kinase Phosphotransfer System in Cell Energetics and AMP Metabolic Signaling

    • The Biological Role of Adenylate Kinase

    • Adenylate Kinase Isoform-based Metabolic Network

    • Adenylate Kinase Catalyzed β-phosphoryl Transfer and Energy Economy

    • Adenylate Kinase–instigated AMP Metabolic Signaling and Energy Sensing

  • Glycolysis as a Network of Phosphotransfer Circuits and Metabolite Shuttles

    • Glycolytic Phosphotransfer Circuits

    • Glycolytic Pi Shuttle

    • Glycolytic Lactate Shuttle

    • Neural Glycolytic Network: Role in Energetics and Information Processing

  • Glycogen Energy Transfer Network: Adding a Spatial Dimension to Glycogenolysis

  • Concluding Remarks: Integration of Phosphotransfer Pathways

  • References

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