Chapter 1. High-Resolution Structures of Membrane Proteins: From X-Ray Crystallography to an Integrated Approach of Membranes

  1. Prof. Eva Pebay-Peyroula PhD professor
  1. Prof. Eva Pebay-Peyroula PhD professor

Published Online: 7 JAN 2008

DOI: 10.1002/9783527621224.ch1

Biophysical Analysis of Membrane Proteins: Investigating Structure and Function

Biophysical Analysis of Membrane Proteins: Investigating Structure and Function

How to Cite

Pebay-Peyroula, E. (2007) High-Resolution Structures of Membrane Proteins: From X-Ray Crystallography to an Integrated Approach of Membranes, in Biophysical Analysis of Membrane Proteins: Investigating Structure and Function (ed E. Pebay-Peyroula), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527621224.ch1

Editor Information

  1. Institut de Biologie Structurale Jean-Pierre Ebel, Université Joseph Fourier-CEA-CNRS, 41 rue Jules Horowitz, 38027 Grenoble cedex 1, France

Author Information

  1. Institut de Biologie Structurale Jean-Pierre Ebel, Université Joseph Fourier-CEA-CNRS, 41 rue Jules Horowitz, 38027 Grenoble cedex 1, France

Publication History

  1. Published Online: 7 JAN 2008
  2. Published Print: 24 OCT 2007

ISBN Information

Print ISBN: 9783527316779

Online ISBN: 9783527621224

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Keywords:

  • biophysical analysis;
  • membrane proteins;
  • X-ray crystallography;
  • structures

Summary

This chapter contains sections titled:

  • Membranes: A Soft Medium?

  • Current Knowledge on Membrane Protein Structures

    • An Overview of the Protein Data Bank

    • Protein Sources for Structural Studies

    • The Diversity of Membrane Protein Topologies

    • Genome Analyses

  • X-Ray Crystallography

    • Crystallization of Membrane Proteins

    • General Aspects of Crystallography

    • Determining the Phases Associated with Diffracted Waves

    • Structure Determination of Membrane Proteins

      • Crystal Quality

      • Phase Determination

      • Crystal Freezing

  • Recent Examples

    • Bacterial Rhodopsins

    • ADP/ATP Carrier

    • Oligomerization of Membrane Proteins in their Natural Environment

  • Future Developments in X-Ray Crystallography of Membrane Proteins

  • Conclusions