Chapter 4. Exploiting Enantioselectivity of Hydrolases in Organic Solvents

  1. Dr. Giacomo Carrea,
  2. Dr. Sergio Riva
  1. Hans-Erik Högberg

Published Online: 21 FEB 2008

DOI: 10.1002/9783527621729.ch4

Organic Synthesis with Enzymes in Non-Aqueous Media

Organic Synthesis with Enzymes in Non-Aqueous Media

How to Cite

Högberg, H.-E. (2008) Exploiting Enantioselectivity of Hydrolases in Organic Solvents, in Organic Synthesis with Enzymes in Non-Aqueous Media (eds G. Carrea and S. Riva), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527621729.ch4

Editor Information

  1. Istituto di Chimica del Riconoscimento Molecolare, C.N.R., Via Mario Bianco 9, 20131 Milano, Italy

Author Information

  1. Mid Sweden University, Department of Natural Science, S-851 70 Sundsvall, Sweden

Publication History

  1. Published Online: 21 FEB 2008
  2. Published Print: 13 FEB 2008

ISBN Information

Print ISBN: 9783527318469

Online ISBN: 9783527621729

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Keywords:

  • biocatalysis;
  • organic solvents;
  • enantioselectivity;
  • hydrolases;
  • desymmetrization

Summary

This chapter contains sections titled:

  • Introduction

    • Enantioselectivity

    • Desymmetrization

    • The Reversibility Problem

    • Determining and Optimizing Enantioselectivity

  • Enantioselective Reactions in Organic Solvents

    • Reactions of Alcohols

      • Primary Alcohols

      • Secondary Alcohols

      • Tertiary Alcohols

      • Resolution of Dihydroxybiaryls

    • Reaction of Amines

      • Alkylamines

      • Arylalkylamines

      • Amino Acid Derivatives

    • Reaction of Acid Derivatives

      • Acids

      • Other Acid Derivatives

  • Summary and Outlook