Chapter 7. Industrial-Scale Applications of Enzymes in Non-Aqueous Solvents

Summary

This chapter contains sections titled:

• Introduction

• Ester Synthesis by Esterification

• Resolution of Racemic Alcohols

  • Synthesis of a Chiral R-(+) Hydromethyl Glutaryl Coenzyme A Reductase Inhibitor (Anticholesterol Drug)

  • The Synthesis of S-N(tert-Butoxycarbonyl)-3-Hydroxymethylpiperidine (Tryptase Inhibitor)

  • The Synthesis of (S)-[1-(Acetoxyl)-4-(3-Phenyl)Butyl]Phosphonic Acid Diethyl Ester (Anticholesterol Drug)

  • Synthesis of Desoxyspergualin (Immunosuppressant and Antitumor Drug)

  • Dynamic Kinetic Resolution of Racemic Alcohols

• Kinetic Resolution of Racemic Amines

  • Resolution of Rac-2-Butylamine

  • Synthesis of a Selective, Non-Peptide, Non-Sulfhydryl Farnesyl Protein Transfer Inhibitor (Antitumor Agent)

• Resolution of Amino Alcohols and Methyl Ethers

• Resolution of an Ester

  • Ester Resolution for the Synthesis of Emtricitabine (Antiviral Drug)

• Desymmetrization by Transesterification

  • Synthesis of an Antifungal Azole Derivative

• Regioselective Acylation

  • Regioselective Acylation of Drug Intermediate for an Antileukaemic Agent

  • Regioselective Acylation of Ribavirin: Antiviral Agent

• Asymmetric Ring Opening of Racemic Azlactone

  • Synthesis of (S)-Benzyl-L-tert-Leucine Butyl Ester

  • Synthesis of (S)-γ-Fluoroleucine Ethyl Ester

• Cyanohydrin Formation

  • Synthesis of (R)-2-Chloromandelic Acid: Intermediate for Clopidogrel

  • Synthesis of Chiral Phenoxybenzaldehyde Cyanohydrin: Intermediate for the Synthesis of Pyrethroid Insecticides

  • Hydrocyanation of 3-Pyridinecarboxyaldehyde

• Outlook