Chapter 5. Biocatalysis

  1. Dr. Gadi Rothenberg

Published Online: 3 MAR 2008

DOI: 10.1002/9783527621866.ch5

Catalysis: Concepts and Green Applications

Catalysis: Concepts and Green Applications

How to Cite

Rothenberg, G. (2008) Biocatalysis, in Catalysis: Concepts and Green Applications, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527621866.ch5

Author Information

  1. Van't Hoff Institute for Molecular Sciences, University of Amsterdam, The Netherlands www.science.uva.nl/˜gadi

Publication History

  1. Published Online: 3 MAR 2008
  2. Published Print: 29 JAN 2008

ISBN Information

Print ISBN: 9783527318247

Online ISBN: 9783527621866

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Keywords:

  • catalysis;
  • green chemistry;
  • biocatalysis;
  • enzymatic catalysis;
  • applications;
  • new biocatalysts development;
  • nonenzymatic biocatalysts;
  • industrial examples

Summary

This chapter contains sections titled:

  • The Basics of Enzymatic Catalysis

    • Terms and Definitions – The Bio Dialect

    • Active Sites and Substrate Binding Models

    • Intramolecular Reactions and Proximity Effects

    • Common Mechanisms in Enzymatic Catalysis

  • Applications of Enzyme Catalysis

    • Whole-Cell Systems versus Isolated Enzymes

    • Immobilized Enzymes: Bona Fide Heterogeneous Catalysis

      • Binding Enzymes to Solid Supports

      • Trapping Enzymes in Polymers or Sol/Gel Matrices

      • Cross-Linking of Enzymes

    • Replacing “Conventional Routes” with Biocatalysis

    • Combining “Bio” and “Conventional” Catalysis

  • Developing New Biocatalysts: Better than Nature's Best

    • Prospecting Natural Diversity

    • Rational Design

    • Directed Evolution

  • Nonenzymatic Biocatalysts

    • Catalytic Antibodies (Abzymes)

    • Catalytic RNA (Ribozymes)

  • Industrial Examples

    • High-Fructose Corn Syrup: 11 Million Tons per Year

    • The Mitsubishi Rayon Acrylamide Process

    • The BMS Paclitaxel Process

    • The Tosoh/DSM Aspartame Process

  • Exercises

  • References