Chapter 8. Regulatory Networks in Pseudomonas aeruginosa: Role of Cyclic-di(3′,5′)-Guanylic Acid

  1. Prof. Dr. Bernd H. A. Rehm
  1. Ute Römling1 and
  2. Susanne Häussler2

Published Online: 31 MAR 2008

DOI: 10.1002/9783527622009.ch8

Pseudomonas: Model Organism, Pathogen, Cell Factory

Pseudomonas: Model Organism, Pathogen, Cell Factory

How to Cite

Römling, U. and Häussler, S. (2008) Regulatory Networks in Pseudomonas aeruginosa: Role of Cyclic-di(3′,5′)-Guanylic Acid, in Pseudomonas: Model Organism, Pathogen, Cell Factory (ed B. H. A. Rehm), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527622009.ch8

Editor Information

  1. Institute of Molecular BioSciences, Massey University, Private Bag 11222, Palmerston North 4442, New Zealand

Author Information

  1. 1

    Karolinska Institutet, Department of Microbiology, Tumor and Cell Biology, Box 280, 17 177 Stockholm, Sweden

  2. 2

    Helmholtz Zentrum für Infektionsforschung GmbH, Department of Cell Biology, Inhoffenstrasse 7, 38124 Braunschweig, Germany

Publication History

  1. Published Online: 31 MAR 2008
  2. Published Print: 26 MAR 2008

ISBN Information

Print ISBN: 9783527319145

Online ISBN: 9783527622009

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Keywords:

  • regulatory networks;
  • pseudomonas aeruginosa;
  • cyclic-di(3′,5′)-guanylic acid;
  • c-di-GMP signaling principles;
  • motility;
  • sessility;
  • GGDEF domain proteins;
  • EAL domain proteins;
  • biofilm formation;
  • fimbrial biogenesis;
  • exopolysaccharide production;
  • formation of small colony variants;
  • virulence;
  • c-di-GMP-binding proteins

Summary

This chapter contains sections titled:

  • Introduction – The History of Cyclic-di(3′,5′)-Guanylic Acid Detection

  • Principles of c-di-GMP Signaling

    • Transition between Motility and Sessility

    • Di-guanylate Cyclases

    • Phosphodiesterases

    • Principle Concepts of c-di-GMP Signaling

  • GGDEF and EAL Domain Proteins in P. aeruginosa

  • c-di-GMP Signaling in Biofilm Formation

  • c-di-GMP Signaling in Fimbrial Biogenesis

  • c-di-GMP Signaling in Exopolysaccharide Production

  • c-di-GMP Signaling and Motility

  • c-di-GMP Signaling in the Formation of Small Colony Variants

  • c-di-GMP Signaling in Virulence

  • c-di-GMP-Binding Proteins in P. aeruginosa

  • Perspectives

  • References