Chapter 1. The Ins and Outs of Integrin Signaling

  1. Prof. Dr. Susan E. LaFlamme2,
  2. Prof. Andrew P. Kowalczyk3
  1. Asoka Banno,
  2. Mark H. Ginsberg

Published Online: 11 APR 2008

DOI: 10.1002/9783527622092.ch1

Book Title

Cell Junctions: Adhesion, Development, and Disease

Cell Junctions: Adhesion, Development, and Disease

Additional Information

How to Cite

Banno, A. and Ginsberg, M. H. (2008) The Ins and Outs of Integrin Signaling, in Cell Junctions: Adhesion, Development, and Disease (eds S. E. LaFlamme and A. P. Kowalczyk), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527622092.ch1

Editor Information

  1. 2

    Albany Medical College, Center for Cell Biology and Cancer Research, 47 New Scotland Avenue, Albany, NY 12208, USA

  2. 3

    Emory University School of Medicine, Departments of Cell Biology and Dermatology, 615 Michael Street, Atlanta, GA 30322, USA

Author Information

  1. University of California, San Diego, Department of Medicine, 9500 Gilman Drive, MC 0726, San Diego, CA 92093-0726, USA

Publication History

  1. Published Online: 11 APR 2008
  2. Published Print: 26 MAR 2008

ISBN Information

Print ISBN: 9783527318827

Online ISBN: 9783527622092

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CHAPTER TOOLS

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Keywords:

  • cell junctions;
  • cell–matrix junctions;
  • integrin signalling;
  • integrin activation

Summary

This chapter contains sections titled:

  • General Overview

    • Integrin Receptors

    • Functions

  • Integrin Activation

    • Definition

      • Platelets

      • Leukocytes

    • Structural Basis of Activation

      • Extracellular Rearrangements

      • Transmembrane Propagation

      • Intracellular Rearrangements

      • Interactions at the Integrin Cytoplasmic Domains

    • Regulation of Integrin Activation

    • Future Research Directions

  • References

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