Chapter 11. Tight Junctions in Simple and Stratified Epithelium

  1. Prof. Dr. Susan E. LaFlamme3,
  2. Prof. Andrew P. Kowalczyk4
  1. Cara J. Gottardi1,
  2. Carien M. Niessen2

Published Online: 11 APR 2008

DOI: 10.1002/9783527622092.ch11

Book Title

Cell Junctions: Adhesion, Development, and Disease

Cell Junctions: Adhesion, Development, and Disease

Additional Information

How to Cite

Gottardi, C. J. and Niessen, C. M. (2008) Tight Junctions in Simple and Stratified Epithelium, in Cell Junctions: Adhesion, Development, and Disease (eds S. E. LaFlamme and A. P. Kowalczyk), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527622092.ch11

Editor Information

  1. 3

    Albany Medical College, Center for Cell Biology and Cancer Research, 47 New Scotland Avenue, Albany, NY 12208, USA

  2. 4

    Emory University School of Medicine, Departments of Cell Biology and Dermatology, 615 Michael Street, Atlanta, GA 30322, USA

Author Information

  1. 1

    Northwestern University, Feinberg School of Medicine, Department of Medicine, Division of Pulmonary and Critical Care, 240 East Huron St., Chicago, IL 60611, USA

  2. 2

    University of Cologne, Center for Molecular Medicine, Joseph Stelzmannstrasse 9, 50931 Köln, Germany

Publication History

  1. Published Online: 11 APR 2008
  2. Published Print: 26 MAR 2008

ISBN Information

Print ISBN: 9783527318827

Online ISBN: 9783527622092

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CHAPTER TOOLS

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Keywords:

  • cell junctions;
  • tight junctions;
  • simple epithelium;
  • stratified epithelium;
  • ultrastructure of tight junctions;
  • epithelial barrier function;
  • regulation;
  • epithelial polarity;
  • signaling from tight junctions;
  • tight junctions and disease

Summary

This chapter contains sections titled:

  • Introduction

  • Ultrastructure of Tight Junctions

  • Tight Junctions and Epithelial Barrier Function

    • Transmembrane Components

    • Scaffolding Proteins

    • Actin and Related Cytoskeleton Proteins

  • Regulation of Tight Junction Barrier Function

  • Tight Junctions and Epithelial Polarity

    • Par3/Par6/aPKC Complex

    • Crbs/Patj/Pals

    • Fence Function

  • Signaling from Tight Junctions: Coupling Junction Maturation to Transcription-Mediated Differentiation

  • Tight Junctions in Stratifying Epithelia

  • Tight Junctions and Disease

  • Concluding Remarks

  • Acknowledgments

  • References

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