Chapter 11. Tight Junctions in Simple and Stratified Epithelium

  1. Prof. Dr. Susan E. LaFlamme3 and
  2. Prof. Andrew P. Kowalczyk4
  1. Cara J. Gottardi1 and
  2. Carien M. Niessen2

Published Online: 11 APR 2008

DOI: 10.1002/9783527622092.ch11

Cell Junctions: Adhesion, Development, and Disease

Cell Junctions: Adhesion, Development, and Disease

How to Cite

Gottardi, C. J. and Niessen, C. M. (2008) Tight Junctions in Simple and Stratified Epithelium, in Cell Junctions: Adhesion, Development, and Disease (eds S. E. LaFlamme and A. P. Kowalczyk), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527622092.ch11

Editor Information

  1. 3

    Albany Medical College, Center for Cell Biology and Cancer Research, 47 New Scotland Avenue, Albany, NY 12208, USA

  2. 4

    Emory University School of Medicine, Departments of Cell Biology and Dermatology, 615 Michael Street, Atlanta, GA 30322, USA

Author Information

  1. 1

    Northwestern University, Feinberg School of Medicine, Department of Medicine, Division of Pulmonary and Critical Care, 240 East Huron St., Chicago, IL 60611, USA

  2. 2

    University of Cologne, Center for Molecular Medicine, Joseph Stelzmannstrasse 9, 50931 Köln, Germany

Publication History

  1. Published Online: 11 APR 2008
  2. Published Print: 26 MAR 2008

ISBN Information

Print ISBN: 9783527318827

Online ISBN: 9783527622092



  • cell junctions;
  • tight junctions;
  • simple epithelium;
  • stratified epithelium;
  • ultrastructure of tight junctions;
  • epithelial barrier function;
  • regulation;
  • epithelial polarity;
  • signaling from tight junctions;
  • tight junctions and disease


This chapter contains sections titled:

  • Introduction

  • Ultrastructure of Tight Junctions

  • Tight Junctions and Epithelial Barrier Function

    • Transmembrane Components

    • Scaffolding Proteins

    • Actin and Related Cytoskeleton Proteins

  • Regulation of Tight Junction Barrier Function

  • Tight Junctions and Epithelial Polarity

    • Par3/Par6/aPKC Complex

    • Crbs/Patj/Pals

    • Fence Function

  • Signaling from Tight Junctions: Coupling Junction Maturation to Transcription-Mediated Differentiation

  • Tight Junctions in Stratifying Epithelia

  • Tight Junctions and Disease

  • Concluding Remarks

  • Acknowledgments

  • References