Chapter 12. Desmosomes in Development and Disease

  1. Prof. Dr. Susan E. LaFlamme3 and
  2. Prof. Andrew P. Kowalczyk4
  1. Ansgar Schmidt1 and
  2. Peter J. Koch2

Published Online: 11 APR 2008

DOI: 10.1002/9783527622092.ch12

Cell Junctions: Adhesion, Development, and Disease

Cell Junctions: Adhesion, Development, and Disease

How to Cite

Schmidt, A. and Koch, P. J. (2008) Desmosomes in Development and Disease, in Cell Junctions: Adhesion, Development, and Disease (eds S. E. LaFlamme and A. P. Kowalczyk), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527622092.ch12

Editor Information

  1. 3

    Albany Medical College, Center for Cell Biology and Cancer Research, 47 New Scotland Avenue, Albany, NY 12208, USA

  2. 4

    Emory University School of Medicine, Departments of Cell Biology and Dermatology, 615 Michael Street, Atlanta, GA 30322, USA

Author Information

  1. 1

    Philipps-University of Marburg Medical School, Institute of Pathology, Baldingerstrasse, 35033 Marburg, Germany

  2. 2

    University of Colorado at Denver and Health Science Center, Department of Dermatology, 12800 East 19th Avenue, Aurora, CO 80045, USA

Publication History

  1. Published Online: 11 APR 2008
  2. Published Print: 26 MAR 2008

ISBN Information

Print ISBN: 9783527318827

Online ISBN: 9783527622092



  • cell junctions;
  • desmosomes in development;
  • desmosomes in disease;
  • molecular composition of desmosomes;
  • animal models;
  • plakoglobin;
  • plakophilins;
  • accessory desmosomal proteins;
  • desmosomal proteins in embryonic development


This chapter contains sections titled:

  • Introduction

  • Molecular Composition of Desmosomes, Disease Associations, and Animal Models

    • Desmosomal Cadherins

    • Desmoplakin

  • Plakoglobin

  • Plakophilins

  • Accessory Desmosomal Proteins

  • Desmosomal Proteins in Embryonic Development

  • Concluding Remarks

  • Acknowledgments

  • References